Dual-Target CAR-NK Cells in Recurrent or Refractory Epithelial Ovarian Cancer
Recruiting
Phase 1
Phase 2
Interventional Study
Epithelial Ovarian Cancer
Epithelial Ovarian Cancer, Fallopian Tube or Peritoneum
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 75
- Sex
- Female
- Trial phase
- Phase 1/2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 42 (estimated)
- Sponsor
- Beijing Biotech · Industry
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About This Trial
This study evaluates the safety, tolerability, and preliminary anti-tumor activity of EB-DUALNK, a dual-target chimeric antigen receptor natural killer (CAR-NK) cell therapy, in adults with recurrent or refractory epithelial ovarian cancer. Candidates for targeting include GD2, MUC1, PSMA, and mesothelin. After baseline biomarker assessment (tumor antigen expression), the program will select the m…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 18-75 years; able to provide written informed consent.
* Histologically confirmed epithelial ovarian, fallopian tube, or primary peritoneal carcinoma that is recurrent or refractory after standard therapy (at least 2 prior systemic regimens), with measurable disease per RE…
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