Resveratrol Treatment for Parkinson's Disease

RESvEraTrol in Parkinson's Disease (RESET)

Recruiting Phase 2 Interventional Study
Parkinson's Disease
Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
55 – 85
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Other
Participants needed
30 (estimated)
Sponsor
Georgetown University · Other
Who this trial is looking for

This trial is looking for individuals with Parkinson's Disease who are stable on their medication. Participants will take a daily dose of a study drug for three months to help understand its safety and effects.

Are You a Good Fit for This Trial?
Must be taking LevodopaDA agonists
Must not be taking CoumadinHeparinEnoxaparinFondaparinux
Rules you out Alzheimer's DiseaseMultiple system atrophyChronic traumatic encephalopathy

You may be able to join if

  • I can provide informed consent.
  • I have been diagnosed with Parkinson's Disease.
  • I have been on Levodopa or DA agonists for at least 4 weeks.
  • I am aged 55 to 85 years.
  • I speak English fluently.
  • I have a MoCA score of at least 18.
  • I am in Hohn and Yahr stage 2 or 3.
  • I am medically stable.

You may not be able to join if

  • I have known Parkinson's disease-related gene mutations.
  • I have any psychiatric diagnosis that affects my study participation.
  • I have any uncontrolled medical conditions.
  • I have had a major stroke or head injury.
  • I am currently enrolled in another clinical study.
  • I have severe visual or hearing impairments.
  • I am a woman who can become pregnant or am breastfeeding.
  • I have a Geriatric Depression Scale score of 8 or higher.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

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About This Trial
This is an exploratory phase 2a study to investigate two doses of resveratrol (JotrolTM) vs placebo in individuals diagnosed with Parkinson's Disease (PD). Participants (n=30) will be randomized 1:1:1 into 3 groups and will receive oral JotrolTM vs placebo. Study drug will be titrated to reach a final maximal dose per group and will be administered orally once daily (QD) for 3 months. The study wi…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Capable of providing informed consent (IC) and complying with study procedures * Stable on Levodopa and/or DA agonists for at least 4 weeks before enrollment * Clinical diagnosis of PD according to UK Brain Bank criteria and/or PD with Dementia (PDD) by MDS criteria (53-55). *…
Contacts

Luke Lovelace, BS, MBA

757-802-5001

ll928@georgetown.edu

CONTACT

Michaeline Hebron, BA, MS

570-677-4803

mlh88@georgetown.edu

CONTACT