No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
20 – 70
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Basic Science
Participants needed
30 (estimated)
Sponsor
The Catholic University of America · Other
Who this trial is looking for
This trial is looking for people who have had a stroke at least 6 months ago. Participants will do hand movements in a virtual reality environment while their muscle activity is recorded.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 20 and 70 years old
I had my first stroke on one side of my brain
I have some weakness on one side of my body
It has been at least 6 months since my stroke
I scored between 31 and 55 on the Fugl-Meyer test
You may not be able to join if
I have a serious medical condition
I feel pain in my hand or arm when I move
I cannot move my fingers or thumb voluntarily
I cannot give my consent to participate
I have an injury like a fracture or severe heart disease
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The following experiment will be conducted with 15 chronic stroke survivors and 15 control subjects. Subjects will perform hand movements in the virtual reality environment using a head-mounted display. Quest's onboard cameras allow real-time tracking of hand motion, estimating joint angles of the finger and the thumb. For each feedback manipulation condition (i.e., movement amplification or reduc…
The following experiment will be conducted with 15 chronic stroke survivors and 15 control subjects. Subjects will perform hand movements in the virtual reality environment using a head-mounted display. Quest's onboard cameras allow real-time tracking of hand motion, estimating joint angles of the finger and the thumb. For each feedback manipulation condition (i.e., movement amplification or reduction), the estimated joint angles will be multiplied by a factor greater than 1 (amplification) or a factor smaller than 1 (reduction). Then the newly-estimated hand posture will be displayed in the VR environment. Subjects will be randomly assigned into two groups (A and B), who will receive the assistance in a different order. Subjects will perform finger extension under three conditions: no sensory modulation, movement visual feedback (VF) amplification, and movement VF reduction (error augmentation), while their movement muscle activation patterns are recorded.
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Eligibility Criteria
Inclusion Criteria for stroke group:
* Age: 20 - 70 years old
* First-ever unilateral cortical stroke with resultant hemiparesis at least 6 months prior to the experimental testing
* Fugl-Meyer Upper Extremity Section 31 - 55
Exclusion Criteria for both groups:
* Presence of concurrent severe med…
Inclusion Criteria for stroke group:
* Age: 20 - 70 years old
* First-ever unilateral cortical stroke with resultant hemiparesis at least 6 months prior to the experimental testing
* Fugl-Meyer Upper Extremity Section 31 - 55
Exclusion Criteria for both groups:
* Presence of concurrent severe medical illness
* Pain in hand or arm with movements
* Loss of voluntary control of fingers and thumb
* Inability to provide informed consent
* Musculoskeletal injuries (e.g., fracture) or medical complications (e.g., severe cardiovascular disease).
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