Sepsis Multiomic Analysis & Risk sTratification in China

Inclusion Criteria - Sepsis Group: * Age ≥ 18 years * Meets the Sepsis-3 diagnostic criteria: confirmed or suspected infection with an increase in SOFA score of ≥ 2 points from baseline * Develops sepsis within 72 hours of ICU admission * Voluntarily signs the informed consent form (or signed by the legal representative) Inclusion Criteria - Non-Sepsis Group: * Age ≥ 18 years * Hospitalized in the ICU during the same period, with no clear evidence of infection and not meeting the diagnostic criteria for sepsis * Expected ICU treatment time ≥ 24 hours * Voluntarily signs the informed consent form (or signed by the legal representative) Exclusion Criteria: * End-stage chronic organ failure (end-stage renal disease, decompensated liver cirrhosis \[Child-Pugh Grade C\], or chronic heart failure NYHA Class IV), or malignant tumor * Immunocompromised, autoimmune disease, or long-term use of glucocorticoids/immunosuppressants within the past 3 months * Pregnant or postpartum patients * Other conditions deemed unsuitable by the investigator (e.g., terminal state, refusal to cooperate with sample collection, or inability to cooperate with in-hospital and out-of-hospital follow-up)