Chemotherapy Induced Peripheral Neuropathy by Taxanes and Capsaicin 8%.

Inclusion Criteria: * patients over 18 years of age with no age limit * having given their signed consent for participation in the study * affiliated with the social security system * able to be followed for the entire duration of the study * reading and understanding French * accepting the principle of the study and able to respect its conditions * presenting sensorimotor or sensory neuropathy induced by taxanes (paclitaxel or docetaxel) of the lower limbs for at least 3 months based on a complete clinical examination, the severity of which will be assessed by the NCI-CTCAE version 5 criteria (grade 2 to 4). An electromyogram (EMG) will be performed in the absence of a recent electromyogram (less than one year) to assess the function of large fibers, but its normality will not constitute an exclusion criterion (due to the possibility of chemotherapy-induced small fiber neuropathies). * presenting chronic neuropathic pain in the lower limbs for at least 3 months, with a DN4 questionnaire score ≥ 4/10 and of at least moderate intensity on an 11-point numerical scale (≥ 4/10) * whose pain is located in the lower limbs allowing the application of 8% capsaicin * without treatment or having stable analgesic treatment for at least 2 weeks before inclusion Exclusion Criteria: * litigation or compensation-seeking * metastatic cancer * Known cause of sensory neuropathy such as diabetes, systemic disease, hypothyroidism, alcohol, kidney failure, or genetic disease * Peripheral or central nervous system pathology with or without associated neuropathic pain * Uncontrolled chronic pathology such as morbid obesity, sleep apnea, uncontrolled hypertension, etc. * Psychosis, previous suicide attempt, or major depressive episode at the time of assessment * Drug or psychoactive substance abuse * Cognitive or psychological disorders incompatible with compliance with and/or understanding of the protocol * Patients participating in another biomedical research protocol * Contraindications to confocal corneal microscopy, including the wearing of long-term contact lenses or ocular procedures (eye surgery, laser for myopia, dry eye). * Pregnant or breastfeeding women * Persons under legal protection