No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
25 – 50
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
25 (estimated)
Sponsor
Pennington Biomedical Research Center · Other
Who this trial is looking for
This trial is looking for adults aged 25-50 who have early signs of blood sugar problems. Participants will eat a small amount of almonds before meals to see if it helps control their blood sugar levels.
Are You a Good Fit for This Trial?
Rules you outType 1 diabetesType 2 diabetes
You may be able to join if
I am aged 25-50 years old
My BMI is between 18.5 and 55.0
I have impaired blood glucose levels
I can read, speak, and understand English
I am willing to comply with study foods
I can take acetaminophen as part of the study
You may not be able to join if
I have lost or gained 5% of my weight in the last 6 months
I have been diagnosed with any cardiovascular, renal, or liver disease in the past year
I have been diagnosed with cancer (except skin cancer) in the last 5 years
I have been diagnosed with diabetes
I have had gastrointestinal or neurological disorders in the past year that are not stable
I have had psychiatric disorders in the past year that are not stable
I cannot eat the study foods due to food allergies
I smoke or vape or have done so in the past 6 months
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The goal of this study is to learn whether eating a small serving of almonds before meals can improve blood sugar control in adults who have early signs of problems with blood sugar regulation. The main questions it aims to answer are:
1. Does eating almonds before a meal reduce the rise in blood sugar after eating?
2. Do some people consistently benefit more than others from eating almonds befor…
The goal of this study is to learn whether eating a small serving of almonds before meals can improve blood sugar control in adults who have early signs of problems with blood sugar regulation. The main questions it aims to answer are:
1. Does eating almonds before a meal reduce the rise in blood sugar after eating?
2. Do some people consistently benefit more than others from eating almonds before meals?
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adults aged 25-50 years
* Females over 40 years must have had a cycle in the last 6 months
* Body mass index (BMI) at least 18.5 and at most 55.0 kg/m2
* Impaired blood glucose by at least one of the following criteria:
* Fasting blood glucose at least 100 mg/dL (5.6 mmol/L) a…
Inclusion Criteria:
* Adults aged 25-50 years
* Females over 40 years must have had a cycle in the last 6 months
* Body mass index (BMI) at least 18.5 and at most 55.0 kg/m2
* Impaired blood glucose by at least one of the following criteria:
* Fasting blood glucose at least 100 mg/dL (5.6 mmol/L) and less than 125 mg/dL (6.9 mmol/L)
* HbA1c at least 5.7% and less than 6.5%
* Willing and able to comply with study foods
* Willing and able to ingest acetaminophen as part of study procedures
* Able to read, speak, and understand English
Exclusion Criteria:
* Weight change ≥5% in past 6 months, actively trying to lose weight, or unwilling to remain weight stable throughout the study based on self-report
* Recent history within past 12 months of medical provider-diagnosed cardiovascular, renal, or liver disease that required treatment
* Current or past diagnosis of cancer (except skin cancer) in the last 5 years
* Current or past diagnosis of type 1 or type 2 diabetes
* Recent history within past 12 months of medical provider-diagnosed gastrointestinal or neurological disorders if not managed/stable for at least 3 months (with or without treatment)
* Recent history within past 12 months of medical provider-diagnosed psychiatric disorders including eating disorders or severe depression if not managed/stable for at least 3 months (with or without treatment)
* Food allergies or other reasons preventing consumption of study foods
* Any glucose-lowering medication except biguanides (e.g., Metformin) if stable for at least 3 months or incretins (i.e., GLP-1RA-based) if stable for at least 3 months
* Current smoking or vaping or history of smoking or vaping in the past 6 months
* Binge and/or heavy drinking (i.e., \>3 drinks on any given occasion and/or \>7 drinks/week)
* Currently pregnant or planning to become pregnant or breastfeed in the next 3 months by self-report
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