No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
45 (estimated)
Sponsor
University of South Carolina · Other
Who this trial is looking for
This trial is looking for people who have had a stroke and experience difficulty with language. Participants will receive a type of brain stimulation to help improve their ability to communicate.
Are You a Good Fit for This Trial?
You may be able to join if
I am right-handed
I am a native English speaker
I have had a single stroke in the left side of my brain
I have been diagnosed with aphasia and specific language difficulties
You may not be able to join if
I have severe trouble understanding spoken language
I have major issues with repeating words
I have conditions that make rTMS unsafe for me
I cannot have an MRI scan
My stroke affected the left anterior temporal lobe
I have severe depression or a history of psychiatric issues
I cannot read
I have a known neurodegenerative disorder
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery. Functional Magnetic Resonance Imaging (fMRI) will provide critical insights into the effects of facilitatory versus inhibitory stimulation on interhemispheric balance. Additionally, this stud…
This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery. Functional Magnetic Resonance Imaging (fMRI) will provide critical insights into the effects of facilitatory versus inhibitory stimulation on interhemispheric balance. Additionally, this study will generate new data on how lesion localization and brain connectivity influence individual responses to rTMS, explaining variability in treatment efficacy.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Right-handedness (assesed using the Edinburgh Handedness Inventory)
* Native English speakers
* Single left hemispheric stroke
* Diagnosis of aphasia and lexicosemantic impairments (e.g., anomia, semantic errors in picture naming or spontaneous speech) confirmed by a Speech an…
Inclusion Criteria:
* Right-handedness (assesed using the Edinburgh Handedness Inventory)
* Native English speakers
* Single left hemispheric stroke
* Diagnosis of aphasia and lexicosemantic impairments (e.g., anomia, semantic errors in picture naming or spontaneous speech) confirmed by a Speech and Language Pathologist or Physician
Exclusion Criteria:
* Severely impaired auditory comprehension (WAB Comprehension score of 0 or 1)
* Major phonological impairments (defined as \> 2 errors in non-word repetition of one- and two-syllable items on the PALPA, 2)
* Contraindications to rTMS (e.g., uncontrolled epilepsy, history of seizures, intracranial ferromagnetic body, cochlear implant, or factors that lower seizure threshold (see Rossi et al., 2021)
* Contraindication to MRI
* Stroke involving the left ATL
* Severe depression or psychiatric history
* Illiteracy
* Known neurodegenerative disorders
* Severe uncorrected visual or hearing impairments
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