Injectable Platelet-Rich Fibrin With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defects

Inclusion Criteria: * Patients of both genders \>18 years old, medically free of systemic diseases affecting periodontal regeneration. * Diagnosis of 'periodontitis' stage III (grades B or C). * Single-rooted and multi-rooted vital teeth in either the maxilla or the mandible. * Presence of comparable bilateral two- or three-walled intrabony defects \[probing pocket depth (PPD), \> 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph\] not in a furcation-involved tooth. Exclusion Criteria: * Patients with systemic illness known to affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc. * Pregnant and lactating women * Current use of any form of tobacco. * Non-surgical periodontal treatment in the past 6 months, or surgical periodontal treatment in the past 12 months. * Degree 2 or 3 mobility of the involved sites.6. * Presence of periapical pathology, acute infection, or subgingival restoration which could interfere with clinical measurements.