No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
1 Day – 17
Sex
Any
Study type
Observational
Participants needed
125 (estimated)
Sponsor
University of Wisconsin, Madison · Other
Who this trial is looking for
This trial is looking for critically ill children who are in the Pediatric Intensive Care Unit. Participants will undergo a painless ultrasound test to measure blood flow in the brain and will be observed for a few days.
Are You a Good Fit for This Trial?
You may be able to join if
I have a parent or guardian who can give consent in English.
I am on a ventilator.
I have a catheter in an artery.
I am currently in the PICU.
I am between 1 day and 17.5 years old.
You may not be able to join if
I have something in my head that prevents safe use of the ultrasound probe.
I have chronic high blood pressure.
My FSS score is greater than 16.
I have a tracheostomy.
Dr. Talal Al Hendawi or Dr. Neil Munjal are not available for my scan.
I am not suitable for the study for any other reason determined by the doctors.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit (PICU). TCD is already used for clinical reasons in many children, but it is not part of routine monitoring for every critically ill child. By using TCD, the investigators hope …
This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit (PICU). TCD is already used for clinical reasons in many children, but it is not part of routine monitoring for every critically ill child. By using TCD, the investigators hope to better understand how brain blood flow changes during illness. They will also track children's functional status from before their illness to the time of PICU discharge to explore how brain blood flow patterns relate to neurological outcomes.125 participants will be enrolled and will be on study while in the PICU, estimated to be 3-14 days.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Has at least one Parent or Legal Guardian who is willing and able to provide informed consent in English
* Mechanically ventilated (Endotracheal tube)
* Indwelling arterial catheter
* Current patient in the American Family Children's Hospital PICU.
* 1 day to 17.5 years of age…
Inclusion Criteria:
* Has at least one Parent or Legal Guardian who is willing and able to provide informed consent in English
* Mechanically ventilated (Endotracheal tube)
* Indwelling arterial catheter
* Current patient in the American Family Children's Hospital PICU.
* 1 day to 17.5 years of age
Exclusion Criteria:
* Subjects with a known or obvious anatomic barrier preventing safe application of the transcranial Doppler probe (e.g., cranial dressings, cranial fixation hardware, ventricular access devices positioned over insonation sites, or bilateral craniectomies)
* Patient with known chronic hypertension
* Admission FSS score \> 16
* Tracheostomized patient
* The designated sub-investigator (Dr. Talal Al Hendawi) and PI (Dr. Neil Munjal) are unavailable to perform the Transcranial Doppler scan at the time of eligibility. All study scans are performed by either Dr. Al Hendawi or Dr.Munjal to ensure standardization and data integrity. Therefore, if they are unavailable (e.g., due to clinical service, leave, or other scheduling constraints), the patient will not be enrolled in the study.
* Not suitable for study participation due to other reasons at the discretion of the investigators
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