No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
50 (estimated)
Sponsor
University of California, San Francisco · Other
Who this trial is looking for
This trial is looking for adults with knee osteoarthritis who can perform physical tasks and do not have recent knee injuries. Participants will undergo imaging tests to help better understand their knee pain.
Are You a Good Fit for This Trial?
You may be able to join if
I am an adult and can give informed consent.
I can perform 25 single-leg squats.
I have not had recent knee injuries or surgeries.
I am not taking investigational drugs.
I have no contraindications to MRI or PET tracing.
I am not taking steroid injections.
I am not pregnant.
I have minimal pain during single-leg squats.
You may not be able to join if
I cannot consent for myself.
I cannot perform 25 single-leg squats with the study leg.
I have had recent knee injuries or surgeries.
I am taking investigational drugs.
I have new contraindications to MRI or PET tracing.
I am taking steroid injections.
I am pregnant.
I have diabetes.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This project aims to develop an \[18F\] fluorodeoxyglucose (FDG) positron emission tomography (PET) / magnetic resonance imaging (MRI) method to locate the painful inflammation in PFJ OA associated with joint loading. \[18F\] FDG PET/MRI is an emerging pain imaging approach with enhanced sensitivity to painful hypermetabolic inflammation through evaluation of intracellular glucose utilization rate…
This project aims to develop an \[18F\] fluorodeoxyglucose (FDG) positron emission tomography (PET) / magnetic resonance imaging (MRI) method to locate the painful inflammation in PFJ OA associated with joint loading. \[18F\] FDG PET/MRI is an emerging pain imaging approach with enhanced sensitivity to painful hypermetabolic inflammation through evaluation of intracellular glucose utilization rate via (\[18F\]FDG PET) and fine anatomy details (MRI). The investigative group has shown its promise in revealing previously unidentified or unspecified pain generators in various musculoskeletal pain conditions. The investigators have also demonstrated the feasibility of visualizing the structural changes between unloaded and loaded knee joints with MRI, which can be easily adopted in the current PET/MRI setting. The main challenge in the proposed \[18F\]FDG PET/MRI approach is to differentiate the normal uptake of FDG for metabolic changes by weight-bearing from abnormal changes indicating eventual pain aggravation by weight-bearing and knee-flexion. The investigators have garnered the following two aims to validate the proposed method by comparing unloaded and loaded knee imaging results between PFJ OA pain patients and asymptomatic, matched controls.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adult with the capacity to give informed consent
* Ability to perform 25 single-leg squats
* No traumatic knee injuries/surgeries since last visit for the parent study (IRB #21-34763)
* No investigational drugs since last visit for the parent study (IRB #21-34763)
* No contrai…
Inclusion Criteria:
* Adult with the capacity to give informed consent
* Ability to perform 25 single-leg squats
* No traumatic knee injuries/surgeries since last visit for the parent study (IRB #21-34763)
* No investigational drugs since last visit for the parent study (IRB #21-34763)
* No contraindications to MRI or PET tracer since last visit for the parent study (IRB #21-34763)
* Not taking steroid injections
* Not pregnant
* Additional inclusion criteria for healthy volunteers: Minimal pain (VAS=0-1) during a series of 25 single-leg squats on one or both legs
Exclusion Criteria:
* Inability to consent for themselves
* Inability to perform 25 single-leg squats with the study leg
* New traumatic knee injuries/surgeries since last visit for the parent study (IRB #21-34763)
* Taking investigational drugs since last visit for the parent study (IRB #21-34763)
* New contraindications to MRI or PET tracer since last visit for the parent study (IRB #21-34763)
* Taking steroid injections
* Pregnant
* Diabetic
* Additional exclusion criteria for healthy volunteers: VAS of 2 or greater during a series of 25 single-leg squats on both legs
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