Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial
Recruiting
Phase 2
Interventional Study
Traumatic Brain Injury
Severe Traumatic Brain Injury
Acute Brain Injury
Neurocritical Care
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 88 (estimated)
- Sponsor
- Erasme University Hospital · Other
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About This Trial
The LIMIT-TBI trial is a multicenter, international, randomized, phase II clinical trial designed to evaluate the feasibility and safety of targeting a neutral fluid balance compared to standard care in critically ill adult patients with traumatic brain injury (TBI).
Fluid therapy is a cornerstone of TBI management, but optimal fluid balance remains uncertain, with both fluid overload and restric…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adult patients with traumatic brain injury (isolated or associated with extracranial injuries), with or without intracranial pressure monitoring
* Admission to the intensive care unit
* Age \>18 years
* Enrollment within 48 hours after ICU admission
Exclusion Criteria:
* Enr…
Contacts