Understanding Scoliosis in Teens and Young Adults
UNderstanding the Causes Of Idiopathic Scoliosis Through the Longitudinal Analysis of Proteomic Markers: the UNCOIL Study
Recruiting
Observational Study
Adolescent Idiopathic Scoliosis (AIS)
Neuromuscular Scoliosis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 10 – 17
- Sex
- Any
- Study type
- Observational
- Participants needed
- 500 (estimated)
- Sponsor
- University of Colorado, Denver · Other
Who this trial is looking for
This trial is looking for young people aged 10-17 with scoliosis, either idiopathic or neuromuscular. Participants will visit a Children's Hospital Colorado location twice, about 6-12 months apart, and give blood samples to help researchers understand scoliosis progression.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 10-17 years old.
- I have idiopathic or neuromuscular scoliosis.
- My scoliosis curve is between 10-50 degrees.
- I receive care for scoliosis at a Children's Hospital Colorado location.
You may not be able to join if
- I have a genetic condition affecting my bones or muscles.
- I was diagnosed with scoliosis before I was 9 years old.
- My spinal curve is greater than 50 degrees.
- I am taking medications that may affect protein levels.
- I am pregnant.
- I have a neurocognitive disorder that is non-verbal or non-ambulatory.
- I have congenital scoliosis.
- I have spine surgery scheduled before the study visit.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
The goal of this observational study is to find clinical, demographic, and protein biomarkers that scoliosis progression (scoliosis curve increases) and/or differ between participants with scoliosis versus those without scoliosis. The investigators aim to answer the following questions:
1. Are age, sex, skeletal maturity, and family history associated with scoliosis curve progression?
2. Do prote…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Patients 10-17 years old with idiopathic or neuromuscular scoliosis with a cobb angle of 10-50° that are currently being seen for their scoliosis at a Children's Hospital Colorado location
Exclusion Criteria:
* Children diagnosed with certain genetic conditions that affect t…
Contacts