Tocotrienol Supplementa as A Senolytic Agent in Middle-aged Adults

Inclusion Criteria: * Generally healthy as assessed by physical examination and blood lab test, including adequate liver and renal function, Neutrophil count \> 1500/mm3, Platelet count 120,000 - 450,000/mm3, Haemoglobin concentration 11.5 to 19.0g/dL for men; 10.5-17.5 g/dL for women, Prothrombin and partial thromboplastin time within normal range, ALT and AST \< 80 IU/L, Creatinine 0.7 to 1.3 mg/dL * Subject of either gender, 35 to 64 years of age (inclusive) * Not allergy to palm oil and vitamin E * Do not take vitamin E supplements over the past 3 months * Provide written informed consent prior to screening * Subject is willing and able to comply with the study visit schedule and procedure, geographic proximity (investigator's discretion) that allows adequate follow up * Subjects understand the study protocol and signed informed consent forms Exclusion Criteria: * Subjects with fat malabsorption * Subjects with chronic conditions such as cardiac diseases (heart failure, myocardial infraction, ischemic heart disease), neurological diseases, diabetes, HIV infection, psychiatric illness/social situations * Subjects with vegan diet * Current smoker or used to smoke in the past 3 months * Subject for surgery or had undergone surgery in the past 3 months * Current or past history of drug, alcohol abuse and cancer * Pregnant and lactating women * History of bleeding tendencies or any condition predisposing to bleeding e.g. thrombocytopenia, abnormal liver function, liver disease (e.g. chronic hepatitis), gastrointestinal ulcers * Any subject taking antibiotics or other medication or dietary supplement which could interfere with the action of tocotrienols * Subjects who are pre-disposed to inherited blood/circulation disorders * Subject who is taking anticoagulants and antithrombotic drugs, e.g. warfarin, aspirin, ticlopidine, heparin, etc.