Mindful Walking for Older Adults at Risk of Dementias
Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias
Recruiting
Phase 2Interventional Study
Older Adults With Elevated Dementia Risk
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
60 and older
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Prevention
Participants needed
54 (estimated)
Sponsor
University of South Carolina · Other
Who this trial is looking for
This trial is looking for older adults who are at risk of dementia and have a sedentary lifestyle. Participants will take part in walking sessions that include mindfulness training over four weeks.
Are You a Good Fit for This Trial?
Rules you outDementiaStrokeEpilepsyParkinson's diseaseDepression
You may be able to join if
I am 60 years old or older
I sit for at least 9 hours a day
I have a family history of dementia
I have noticed problems with my memory
I am currently overweight or obese
I can walk without assistance
I am stable in my health
I can hear and see well enough to participate
You may not be able to join if
I have been diagnosed with dementia or other brain problems
I have been diagnosed with a mental disorder
I cannot complete surveys on a mobile device
I plan to move or have surgery in the next 4 months
I am already part of another study about physical activity
I cannot provide consent due to disabilities
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Mindful walking is a promising and practical strategy because it combines two activities known to support healthy aging: walking and mindfulness. Unlike many structured exercise programs, mindful walking is low intensity, accessible, and easier to sustain in daily life. It may be especially useful for older adults at elevated risk for ADRD. However, most existing mindful walking studies have focus…
Mindful walking is a promising and practical strategy because it combines two activities known to support healthy aging: walking and mindfulness. Unlike many structured exercise programs, mindful walking is low intensity, accessible, and easier to sustain in daily life. It may be especially useful for older adults at elevated risk for ADRD. However, most existing mindful walking studies have focused on mental health outcomes, such as stress reduction, rather than cognitive health. Little is known about whether mindful walking can support cognition or how it may influence brain function. To address this gap and strengthen a future R01 resubmission, the investigators propose a two-arm randomized controlled pilot trial using functional near-infrared spectroscopy (fNIRS), a safe, non-invasive brain imaging method. fNIRS measures brain activity through sensors placed on the scalp and is well-suited for repeated assessments in older adults because it is quiet, portable, painless, and cost-effective. The investigators will recruit racially and ethnically diverse middle-aged and older adults from the Midlands of South Carolina who are at elevated risk for ADRD. Participants will be randomly assigned to one of two groups: mindful walking or walking-only control. Both groups will complete 8 staff-supervised individual sessions over 4 weeks. The mindful walking group will learn and practice simple mindfulness skills while walking in multiple settings, including lab-based, indoor, and outdoor environments, to support real-world use. Findings from this pilot study will provide important evidence on whether mindful walking can support brain and cognitive health in adults at elevated risk for ADRD. The results will also help establish a practical, scalable, and sustainable prevention strategy for underserved aging populations in South Carolina.
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Eligibility Criteria
Inclusion Criteria:
1. Age 60 or older
2. Sedentary (sit ≥9hrs per day) and not meeting the US physical activity guidelines
3. Have at least one of the following ADRD risk factors:
i. family history of ADRD (\>= first-degree relative) ii. subjective experience of cognitive complaints iii. curre…
Inclusion Criteria:
1. Age 60 or older
2. Sedentary (sit ≥9hrs per day) and not meeting the US physical activity guidelines
3. Have at least one of the following ADRD risk factors:
i. family history of ADRD (\>= first-degree relative) ii. subjective experience of cognitive complaints iii. currently overweight or obese (BMI≥25)
4. Adequate hearing, visual and cognitive ability to complete study tasks and assessments
5. Able to walk without others' assistance
6. Medically stable with or without medication (do not expect to have major health status changes or a surgery in the next 4 months)
Exclusion Criteria:
1. Diagnosis of ADRD or other brain abnormalities (i.e., strokes, epilepsy, Parkinson's disease)
2. Diagnosis of mental disorders (i.e., depression)
3. Inability to complete surveys on mobile device or wear the activity monitor (i.e., due to arthritis, physical limitations, or other reasons)
4. Plan to move or have surgery in next 4 months
5. Currently participate in other study involving physical activity or cognitive training that may interfere with the study outcomes
6. Unable to provide consent due to disabilities
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