No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
100 (estimated)
Sponsor
General Hospital of Ningxia Medical University · Other
Who this trial is looking for
This trial is looking for adults aged 18 to 65 who are having weight loss surgery. Participants will receive either lidocaine or a placebo through a tube in their stomach right after surgery to see if it helps reduce nausea and vomiting.
Are You a Good Fit for This Trial?
You may be able to join if
I am 18 to 65 years old
I will have weight loss surgery under general anesthesia
I can give informed consent
You may not be able to join if
I am allergic to lidocaine or similar medicines
I have serious liver or kidney problems
I have a history of epilepsy or heart problems
I am pregnant or breastfeeding
I received lidocaine during my surgery
I have a history of severe nausea and vomiting after surgery
I am having emergency or revision surgery
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The goal of this clinical trial is to learn if intragastric administration of lidocaine can reduce postoperative nausea and vomiting in obese patients undergoing laparoscopic sleeve gastrectomy. The main question it aims to answer is:
Does administering 0.5% lidocaine via an orogastric tube reduce the incidence of postoperative nausea and vomiting (PONV) in the post-anesthesia care unit and withi…
The goal of this clinical trial is to learn if intragastric administration of lidocaine can reduce postoperative nausea and vomiting in obese patients undergoing laparoscopic sleeve gastrectomy. The main question it aims to answer is:
Does administering 0.5% lidocaine via an orogastric tube reduce the incidence of postoperative nausea and vomiting (PONV) in the post-anesthesia care unit and within the first 24 hours after surgery compared to a placebo (normal saline)?
Researchers will compare the Lidocaine Group to the Placebo Group to see if the intervention lowers the PONV incidence.
Participants will:
* Receive the assigned study solution (either 0.5% lidocaine 20ml or normal saline 20ml) through an orogastric tube upon surgery completion and before extubation.
* Have their gastric tube clamped for 5 minutes to ensure mucosal exposure before removal.
* Undergo standardized total intravenous anesthesia and perioperative management according to the study protocol.
* Be assessed for nausea, vomiting, and other outcomes at specified time points postoperatively in the recovery room and at 6, 12, and 24 hours.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Adults aged between 18 and 65 years old;
* American Society of Anesthesiologists (ASA) physical status classification II - III;
* Planned to undergo primary elective laparoscopic sleeve gastrectomy with general anesthesia;
* Capable of giving informed consent.
Exclusion Crite…
Inclusion Criteria:
* Adults aged between 18 and 65 years old;
* American Society of Anesthesiologists (ASA) physical status classification II - III;
* Planned to undergo primary elective laparoscopic sleeve gastrectomy with general anesthesia;
* Capable of giving informed consent.
Exclusion Criteria:
* Known allergy, hypersensitivity or contraindication to lidocaine or amide - type local anesthetics;
* Previous significant liver or kidney dysfunction (e.g., ALT/AST \> 3 times the upper limit of normal, GFR \< 30 mL/min);
* History of epilepsy, cardiac conduction abnormalities or previous diagnosis of malignant hyperthermia;
* Pregnancy or lactation;
* Patients who received systemic lidocaine treatment during the operation;
* History of severe postoperative nausea and vomiting (PONV) or motion sickness, requiring multiple prophylactic medications;
* Emergency or revision bariatric surgery.
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