No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
30 (estimated)
Sponsor
Royal National Orthopaedic Hospital NHS Trust · Other
Who this trial is looking for
This trial is looking for adults with a specific foot deformity called cavovarus feet. Participants will help researchers understand how to identify different types of this condition to find the best treatments.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old
I have been diagnosed with cavovarus foot deformity
I have Charcot-Marie-Tooth disease or another hereditary neuropathy
I am already being treated at the Foot & Ankle Unit at RNOH
I can give written consent to participate
I was previously assessed for cavovarus feet at RNOH
My forefoot morphotype has been identified with specific software
My clinical findings were documented in my medical records
You may not be able to join if
I have had surgery on my hindfoot or midfoot
I am under 18 years old
I am unable to consent
I have previously withdrawn consent for my data use
There is not enough clinical examination data about me in my records
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Cavovarus feet are complex deformities in multiple planes. There is little consensus on the best way to address deformities. Furthermore there are various different phenotypes and we have previously described 4 distinct forefoot morphotypes that exist. It has been hypothesised that the various morphotypes could benefit from differing surgical strategies.
However, identification of forefoot morpho…
Cavovarus feet are complex deformities in multiple planes. There is little consensus on the best way to address deformities. Furthermore there are various different phenotypes and we have previously described 4 distinct forefoot morphotypes that exist. It has been hypothesised that the various morphotypes could benefit from differing surgical strategies.
However, identification of forefoot morphotypes has only been possible thus far using specialised semi-automated software and 3D animating software to manually identify morphotypes. It is therefore not straightforward to identify which patients may benefit from which surgery and this is not translatable to surgeons outside of a specialist centre.
The utility of this classification has been thus far limited to research. There is a burning need to explore ways in which identification of forefoot morphotypes can be translated to other centres using techniques such as basic imaging or clinical examination to identify patients with different morphotypes.
At Royal National Orthopaedic Hospital (RNOH) we have a large, complex cohort of patients with neuromuscular foot and ankle deformity and cavovarus feet. We also have access to advanced imaging techniques which we employ in routine care of our patients. We further have access to the software and previous research tools used to identify forefoot morphotypes.
We have for many years been examining cavovarus feet and documenting the various clinical findings. We also run teaching clinics combined with registrars where patients are routinely examined as part of routine care and pre-operative work up.
Therefore we are ideally and uniquely placed to carry out this research which is an extension of our previous work. Our primary aim is to identify a reproducible method of distinguishing between the various forefoot morphotypes in cavovarus feet in patients with Charcot Marie Tooth disease (CMT). This will include investigating the utility of clinical examination and manual measurements (without specialised software) on weightbearing CT (WBCT). We will also aim to examine the reproducibility of any techniques such as clinical examination.
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Eligibility Criteria
Inclusion Criteria:
* Adult patients aged ≥ 18 years
* Clinical diagnosis of cavovarus foot deformity, AND confirmed Charcot-Marie-Tooth disease or other hereditary sensorimotor neuropathy
* Already under the care of the Foot \& Ankle Unit at RNOH.
Additionally, for PROSPECTIVE element:
• Capacit…
Inclusion Criteria:
* Adult patients aged ≥ 18 years
* Clinical diagnosis of cavovarus foot deformity, AND confirmed Charcot-Marie-Tooth disease or other hereditary sensorimotor neuropathy
* Already under the care of the Foot \& Ankle Unit at RNOH.
Additionally, for PROSPECTIVE element:
• Capacity to provide written informed consent
Additionally, for the RETROSPECTIVE element:
* Previously assessed for cavovarus feet at RNOH
* Forefoot morphotype previously identified using Disior Bonelogic software
* Clinical examination findings documented in medical notes.
Exclusion Criteria:
* Previous surgery to the hindfoot or midfoot
* Age under 18 years
For the PROSPECTIVE element:
• Unable to consent
For the RETROSPECTIVE element:
* Participant has previously withdrawn consent for use of their data in line with NHS Opt-out
* Insufficient clinical examination data recorded in medical notes.
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