Individualizing Anti-TNF Therapy in Patients With Inflammatory Bowel Disease
Recruiting
Observational Study
IBD (Inflammatory Bowel Disease)
Crohn Disease (CD)
Ulcerative Colitis (UC)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 40 (estimated)
- Sponsor
- Shmuel Kivity, MD · Government
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About This Trial
This observational study aims to identify genes that may affect how patients with inflammatory bowel disease respond to anti-TNF treatment and why some patients lose response to treatment over time. The study will examine whether genetic markers can help predict which patients are more likely to respond to anti-TNF therapy.
Participants who have not previously received anti-TNF treatment and are …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Established IBD: Crohn's disease (CD) or ulcerative colitis (UC)
* Anti-TNF naïve
* Clinically active disease (HBI\>5 for CD, p-MS≥ 3 for UC)
* Elevated inflammatory indices CRP\>10 or fecal calprotectin\>250
Exclusion Criteria:
* Unable to provide informed consent
* Anti-TN…
Contacts