The Efficacy and Safety of Temporal Interference Stimulation in the Treatment of Post-Traumatic Stress Disorder

Inclusion Criteria: 1. Age 18-50 years, male or female 2. Diagnosis of PTSD per DSM-5 (assessed by CAPS-5), with symptom duration of at least 3 months, and PTSD as the current primary diagnosis; comorbid depressive disorder or anxiety disorder is allowed 3. If currently receiving psychiatric medication, the dosage must be stable for at least 4 weeks prior to enrollment 4. At least 9 years of education (junior high school or above) Exclusion Criteria: 1. Any DSM-5 diagnosis other than PTSD, depressive disorder, or anxiety disorder 2. PTSD symptoms too severe to complete required assessments 3. Received electroconvulsive therapy (ECT) within the past 6 months 4. Received any other form of neuromodulation within the past 2 months (see Item 3 for ECT) 5. Severe medical illness or any condition that may induce seizures or intracranial hypertension (e.g., cardiovascular or respiratory diseases) 6. History of neurological disorders (e.g., epilepsy, cerebrovascular accident) or brain injury/surgery 7. Presence of intracranial stents, cardiac pacemakers, coronary stents, cochlear implants, or any other MRI-incompatible implants 8. Current significant suicidal behavior risk per investigator judgment 9. Pregnancy or planning to become pregnant during the study period 10. Initiation of structured psychotherapy for PTSD within 3 months prior to screening, with expected change during the 10-week treatment period