Pembrolizumab Registry for Outcomes and Treatment Evaluation in Cervical Cancer

Inclusion criteria for the observation cohort: \- Persistent, recurrent, or metastatic cervical cancer commencing treatment or currently treated with a pembrolizumab containing regimen. Inclusion criteria for the early discontinuation cohort: * Previous inclusion in the observation cohort * Choice made to stop pembrolizumab for one of the following reasons: 1. Confirmed complete response if they had received at least 8 cycles of 3- weekly pembrolizumab, including at least 9 weeks beyond a CR (consistent with KEYNOTE-826 criteria) OR 2. Immune-related toxicity grade ≥ 3 OR 3. Patient's preference (e.g. chronic or invalidating grade 1-2 immune-related toxicity) OR 4. Confirmed partial response if they had received at least 8 cycles of 3- weekly pembrolizumab, including at least 9 weeks beyond a PR (timing consistent with KEYNOTE-826 criteria) * Eligible and willing to discontinue pembrolizumab (with or without discontinuing bevacizumab) Exclusion criteria for all cohorts are: * Malignant other disease other than cervical carcinoma that required active treatment in the past 2 years: Participants with basal cell carcinoma of the skin, squamous cell carcinoma of the skin, transitional cell carcinoma of urothelial cancer, or any carcinoma in situ that have undergone potentially curative therapy are not excluded * Any psychological, familial, sociological or geographical condition or a known psychiatric or substance abuse disorder potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial. This comprises each and every condition or circumstance preventing the patient from showing up to the outpatient controls and/or undergoing the CT-scans, or preventing the patient from (adequately) filling out the questionnaires.