Disitamab Vedotin Plus Intravesical Mitomycin C in HER2-Expressing Intermediate- to High-Risk Non-Muscle-Invasive Bladder Cancer

Inclusion Criteria: * Voluntary participation, signing a written informed consent form; * The age on the date of signing the informed consent form should be no less than 18 years old, regardless of gender; * The subjects have completed the standard TURBT procedure before signing the informed consent form, and no obvious residual tumor lesions were found in the surgical field; * The postoperative pathology clearly diagnosed as non-muscle-invasive bladder cancer, and the main tissue component was more than 50% urothelial carcinoma (transitional cell carcinoma); * The subjects were classified into the intermediate-risk or high-risk group according to the risk classification for NMIBC; * Tumor tissue samples for TURBT must be provided, along with the required relevant pathological reports. Fresh surgical tissues or pathological slides can be sent for examination as well; * The patients were intolerant to BCG or did not accept the BCG infusion treatment plan; * Before treatment, HER2 detection was conducted on the resection specimens in the laboratory: The IHC results confirmed HER2 expression (defined as: IHC 1+, 2+ or 3+); * Clinical non-metastatic bladder cancer (N0, M0) was determined by abdominal computed tomography (CT). Exclusion Criteria: * History of muscle-invasive bladder cancer or metastatic bladder cancer before treatment;History of muscle-invasive bladder cancer or metastatic bladder cancer before treatment; * Imaging results within 3 months before treatment indicated lymph node or other site/organ metastasis; * Imaging results within 3 months before treatment indicated the presence of other urinary system tumors; * Received other systemic anti-cancer treatments within 3 weeks before treatment, including chemotherapy, biological therapy, immunotherapy, targeted therapy, endocrine therapy, and/or investigational drug therapy; * Received bladder radiotherapy for urothelial carcinoma before treatment; * Known to have anaphylaxis or delayed allergic reaction to certain components of vedacitinib or similar drugs; * Within the 3 days prior to the first infusion, the following conditions had not yet been alleviated to CTCAE grade 1:Uncontrolled acute or chronic infections, such as pneumonia, biliary tract infections;Hepatitis B and Hepatitis C infections; dyspnea;Acute or chronic kidney injury; nephrotic syndrome; bladder perforation; urinary tract obstruction; * NYHA rating of 3 or 4; * Symptoms and signs related to cardiovascular diseases: including myocardial infarction, congestive heart failure, arrhythmia, etc.; * Known cerebrovascular accidents; * History of autoimmune diseases (such as inflammatory bowel disease, idiopathic thrombocytopenic purpura, systemic lupus erythematosus, hemolytic anemia, rheumatoid arthritis, etc.); * Known positive HIV serology, Hepatitis C infection and/or Hepatitis B (HepBsAg or core antibody positive and responding after antiviral treatment for Hepatitis B, except for these patients: these patients are allowed to participate in this study; Note: Patients with negative HepBsAg at screening)