No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 65
Sex
Any
Study type
Observational
Participants needed
25 (estimated)
Sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology · Industry
Who this trial is looking for
This trial is looking for adults with insulin-dependent type 2 diabetes. Participants will have their blood tested after eating a special meal and use devices to monitor their glucose and activity over time.
Are You a Good Fit for This Trial?
Must be takingInsulin
You may be able to join if
I am between 18 and 65 years old.
I have been diagnosed with insulin-dependent type 2 diabetes.
I have been using insulin therapy for at least 6 months.
I do not smoke or I haven’t smoked for the past 12 months.
I am in good health with no serious medical issues.
I can give my consent to participate.
I can follow the study's procedures and dietary rules.
You may not be able to join if
I have allergies or intolerances to the foods used in the study.
My hemoglobin level is below 9.5 g/dL.
My blood pressure is above 160/100 mmHg.
I am pregnant or planning to become pregnant during the study.
I have had major surgery or trauma in the last 2 months.
I follow a vegan diet or other strict diet as determined by the study doctor.
I have a history of an eating disorder.
I have donated blood in the last 3 months.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This observational study aims to collect detailed metabolic and physiologic data from adults with insulin-dependent type 2 diabetes mellitus following consumption of a mixed meal tolerance test. Participants will undergo frequent blood sampling over a 4-hour period after consuming a standardized liquid mixed meal to measure glucose, insulin, glucagon, C-peptide, and triglyceride responses. Partici…
This observational study aims to collect detailed metabolic and physiologic data from adults with insulin-dependent type 2 diabetes mellitus following consumption of a mixed meal tolerance test. Participants will undergo frequent blood sampling over a 4-hour period after consuming a standardized liquid mixed meal to measure glucose, insulin, glucagon, C-peptide, and triglyceride responses. Participants will also use continuous glucose monitoring and wearable physical activity tracking devices during free-living conditions.
The purpose of this study is to develop mathematical models and digital representations ("digital twins") of people with type 2 diabetes mellitus. These models may help researchers better understand metabolic responses to meals, physical activity, and diabetes treatments, and may support future development of personalized diabetes technologies and therapies.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Men or women, 18-65 years of age
* Diagnosed with insulin-dependent type 2 diabetes mellitus HbA1c ≥ 6.5% at screening
* Current insulin therapy for ≥ 6 months prior to screening
* Nonsmokers (past smokers can be allowed if they have abstained for a minimum of 12 months)
* Jud…
Inclusion Criteria:
* Men or women, 18-65 years of age
* Diagnosed with insulin-dependent type 2 diabetes mellitus HbA1c ≥ 6.5% at screening
* Current insulin therapy for ≥ 6 months prior to screening
* Nonsmokers (past smokers can be allowed if they have abstained for a minimum of 12 months)
* Judged to be in good health based on medical history (i.e., no clinical evidence of cardiovascular, metabolic, respiratory, renal, gastrointestinal, or hepatic disease)
* Able to provide informed consent
* Able to comply with and perform the procedures requested by the protocol (including dietary restrictions, consumption of study foods, records of food diary, sample collection procedures, and study visit schedule)
Exclusion Criteria:
* Men and women with known or suspected intolerance, allergies, or hypersensitivity to study foods
* Men and women with low hemoglobin (Hgb) levels below 9.5 g/dL at the screening visit, indicating anemia
* Men and women with blood pressure \>160 mmHg (systolic) / 100 mmHg (diastolic) at the screening visit
* Women who are pregnant or planning to become pregnant during the study
* Major trauma or a surgical event within 2 months (or longer depending on trauma or event) and after consultation with PI.
* Vegan or other extreme dietary regimens (e.g., Atkins diet, etc.) as judged by the investigator
* History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional
* Donated blood within the last 3 months
* Unstable weight: gained or lost weight +/- 5 kg (11 lbs) in previous 2 months
* Unusual working hours i.e., working overnight (e.g. 3rd shift)
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