Prospective Investigation of Cirrhotic Cardiomyopathy in Humans
Recruiting
Observational Study
Cirrhotic Cardiomyopathy
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 440 (estimated)
- Sponsor
- Vanderbilt University Medical Center · Other
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About This Trial
Cirrhotic Cardiomyopathy (CCM) is a recognized complication of cirrhosis, but understudied despite recent retrospective data suggesting it may be common, affecting one in three patients with decompensated cirrhosis, and associated with significantly increased risk of death and adverse hepatic and cardiac events. Moreover, evidence from preclinical models and children suggest elevated bile acids in…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Decompensated cirrhosis, defined as cirrhosis with current or prior occurrence of one or more of the following:
* portal hypertension-related bleeding,
* hepatic encephalopathy, and/or
* clinical ascites.
2. Model for End Stage Liver Disease version 3.0 (MELD 3.0) ≥…
Contacts