Assessment of the Effects and Safety of Spermidine Supplementation on Blood Lipids and Body Weight in Overweight or Obese Individuals With Hyperlipidemia

Inclusion Criteria: * Males or females aged 18 to 65 years. * BMI ≥ 24 kg/m², without severe chronic diseases. * Not currently using glucose-lowering or lipid-lowering medications. * Dyslipidemia defined as triglycerides ≥ 1.7 mmol/L or total cholesterol ≥ 5.2 mmol/L. * No active weight loss or weight gain diet within the past 1 month. * No special dietary pattern changes (e.g., ketogenic, vegan, high-protein, meal replacement, intermittent fasting) within the past 1 month. * No use of supplements that may affect polyamine intake (e.g., germ, yeast, fermented extracts, nutritional powders) within the past 2-4 weeks. * Willing and able to provide signed informed consent. Exclusion Criteria: * Diagnosis of acute or severe gastrointestinal disease * Concurrent participation in any other weight-loss therapy * Current use of hypoglycemic or lipid-lowering medications * Participation in any other clinical trial within one month prior to signing the informed consent form * Pregnancy, lactation, or planning a pregnancy during the trial period * Known allergy to cellulose or wheat * History of cancer * Renal insufficiency, indicated by abnormal serum creatinine levels * Hepatic impairment, defined as alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>3 × upper limit of normal (ULN), or total bilirubin (TBIL) \>3 × ULN * Any other condition deemed by the investigator as inappropriate for trial participation