Chatbot Intervention Effects on Resting-State Brain Function in Anhedonia
Recruiting
N/AInterventional Study
Healthy
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 40
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
80 (estimated)
Sponsor
University of Electronic Science and Technology of China · Other
Who this trial is looking for
This trial is looking for college students aged 18-40 who experience feelings of lack of pleasure and depressive symptoms. Participants will take part in sessions using an AI chatbot and have brain imaging done before and after the sessions.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 18 and 40 years old
I am right-handed
I have normal or corrected vision
I have elevated anhedonia and depressive symptoms
You may not be able to join if
I have a history of major brain disorders like epilepsy or stroke
I have a history of severe mental illness like schizophrenia or bipolar disorder
I have struggled with substance or alcohol use in the past year
I am currently at high risk of suicide or severe self-harm
I am using psychiatric medications or had therapy in the last month
I have severe vision or hearing problems that can't be corrected
I have conditions that prevent me from having an MRI
I am pregnant or breastfeeding
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on resting-state brain function in college students with elevated anhedonia and depressive symptoms. The study will use a randomized active-control intervention design with pre- and post-intervention resting-state functional magnetic resonance imaging assessments.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* 18-40 years
* Right-handed
* Normal or corrected normal visual acuity
* Participants must show elevated anhedonia and depressive symptoms at screening, defined as a total score of 22 or higher on the Snaith-Hamilton Pleasure Scale and a score of 14 or higher on the Beck Depres…
Inclusion Criteria:
* 18-40 years
* Right-handed
* Normal or corrected normal visual acuity
* Participants must show elevated anhedonia and depressive symptoms at screening, defined as a total score of 22 or higher on the Snaith-Hamilton Pleasure Scale and a score of 14 or higher on the Beck Depression Inventory
Exclusion Criteria:
* History of major central nervous system disorders, such as epilepsy, traumatic brain injury, stroke, or brain tumors.
* History of severe mental illness, including schizophrenia spectrum disorders, bipolar disorder, or other psychotic disorders.
* History of substance or alcohol use disorder or substance or alcohol misuse within the past 12 months that may affect study participation or outcome assessment.
* Individuals currently at high risk of suicide, severe self-harm, or experiencing an acute psychiatric crisis.
* Individuals who are currently using psychiatric medications or have undergone psychotherapy within the past 4 weeks that may significantly affect mood, motivation, or reward processing.
* Severe vision or hearing impairments that cannot be corrected and would interfere with task performance.
* Contraindications to MRI scanning, including metallic implants, pacemakers, severe claustrophobia, or other conditions incompatible with MRI.
* Pregnancy or breastfeeding.
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