Liver Transplants from HIV Donors for HIV Patients
Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver)
Recruiting
N/AInterventional Study
HIV
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
80 (estimated)
Sponsor
Johns Hopkins University · Other
Who this trial is looking for
This trial is looking for people with HIV who need a liver transplant. It compares liver transplants from donors who also have HIV to those from donors without HIV.
Are You a Good Fit for This Trial?
You may be able to join if
I need a liver transplant or a liver-kidney transplant.
I can understand and give my consent for the study.
I have been diagnosed with HIV.
I am 18 years or older.
My most recent HIV-1 RNA level is less than 50 copies/mL.
I might have a detectable viral load but I can still take safe medicines after the transplant.
You may not be able to join if
I have had progressive multifocal leukoencephalopathy (PML) before.
I am pregnant or breastfeeding.
I have other medical conditions that may make it risky for me to join this study.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This research is being done to better understand opportunistic infections and cancer in transplant recipients with HIV who receive livers from a donor with HIV compared to livers from donors without HIV.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Participant meets local criteria for liver or simultaneous liver kidney (SLK) transplant.
* Participant or legally authorized representative (in accordance with Johns Hopkins Medicine Institutional Review Board (IRB) and local IRB policy) is able to understand and provide info…
Inclusion Criteria:
* Participant meets local criteria for liver or simultaneous liver kidney (SLK) transplant.
* Participant or legally authorized representative (in accordance with Johns Hopkins Medicine Institutional Review Board (IRB) and local IRB policy) is able to understand and provide informed consent.
* Participant has documented HIV infection by any licensed assay or documented history of detectable HIV-1 RNA.
* Participant is ≥ 18 years old.
* Most recent HIV-1 RNA \< 50 copies RNA/mL. Viral blips between 50-400 copies will be allowed as long as there are not consecutive measurements \> 200 copies/mL. Organ recipients who are unable to tolerate Antiretroviral Therapy (ART) due to organ failure or recently started ART may be eligible despite a detectable viral load if safe and effective ART to be used by the recipient after transplantation is described.
Exclusion Criteria:
* Participant has prior progressive multifocal leukoencephalopathy (PML), cryptosporidiosis of \> 1 month duration, or prior primary Central Nervous System (CNS) lymphoma.
* Participant is pregnant or breastfeeding.
* Past or current medical problems or findings from medical history, physical examination, or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.
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