Non-Invasive Brain Stimulation for Early Alzheimer's Disease
NON-INVASIVE BRAIN STIMULATION FOR MEMORY LOSS IN EARLY ALZHEIMER'S DISEASE
Recruiting
N/AInterventional Study
Alzheimer s DiseaseMild Cognitive Impairment (MCI) Due to Alzheimer's DiseaseMild Dementia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
55 – 90
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
40 (estimated)
Sponsor
Chi-Ying (Roy) Lin · Other
Who this trial is looking for
This trial is looking for people with early Alzheimer's disease to see if a treatment called repetitive transcranial magnetic stimulation (rTMS) can help improve memory. Participants will receive treatment over four weeks and undergo memory tests and brain scans.
Are You a Good Fit for This Trial?
You may be able to join if
I have early Alzheimer's disease
I have mild cognitive impairment or mild dementia
I have a MMSE score between 20 and 28
I have a CDR-Sum of Boxes score between 0.5 and 8
I have a positive plasma phosphorylated tau-217 result
You may not be able to join if
I have another neurological or psychiatric condition
I have untreated major depressive disorder
I have a history of seizures
I have metal in my head or near the TMS coil
I have heart failure, renal failure, or hepatic failure
I have substantial alcoholism
I take medications that could affect my cognition
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The goal of this clinical trial is to learn if repetitive transcranial magnetic stimulation (rTMS), a non-invasive form of brain stimulation, can improve short-term memory in people with early Alzheimer's disease (AD). The study will also evaluate the safety of this approach.
The main questions it aims to answer are:
* Does rTMS applied to the cerebellum improve short-term memory in people with …
The goal of this clinical trial is to learn if repetitive transcranial magnetic stimulation (rTMS), a non-invasive form of brain stimulation, can improve short-term memory in people with early Alzheimer's disease (AD). The study will also evaluate the safety of this approach.
The main questions it aims to answer are:
* Does rTMS applied to the cerebellum improve short-term memory in people with early AD?
* How does this stimulation affect brain activity and connectivity measured by MRI?
Researchers will compare active rTMS to sham rTMS (a look-alike procedure that does not deliver brain stimulation) to see if rTMS works to improve memory.
Participants will:
* Complete a screening visit with medical and memory assessments
* Be randomly assigned to receive either active rTMS or sham rTMS (neither participants nor researchers will know the assignment during treatment)
* Receive 20 rTMS sessions over 4 weeks (about 20 to 30 minutes per session)
* Undergo two MRI scans, one before and one after treatment
* Complete memory and thinking tests and questionnaires at baseline, immediately after treatment, and at 3- and 6-month follow-up visits
Participation in the study will last about 6 months.
The rTMS is generally well tolerated. The most common side effects include mild headache and scalp discomfort during treatment, which are usually short-lasting. MRI is non-invasive and safe for most people. Study procedures will be reviewed to ensure participant safety.
Participants may or may not benefit directly from this study. People who receive active rTMS may experience improvement in memory. This research may help improve understanding of memory function in AD and support development of new treatments.
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Eligibility Criteria
Inclusion Criteria:
Participants must meet all of the following inclusion criteria to be eligible for enrollment:
* A clinical diagnosis of early AD, defined as either mild cognitive impairment (MCI) due to AD or mild dementia due to AD;
* Evidence of cognitive impairment, characterized by a MMSE …
Inclusion Criteria:
Participants must meet all of the following inclusion criteria to be eligible for enrollment:
* A clinical diagnosis of early AD, defined as either mild cognitive impairment (MCI) due to AD or mild dementia due to AD;
* Evidence of cognitive impairment, characterized by a MMSE score between 20 and 28 and/or a CDR-Sum of Boxes score between 0.5 and 8, consistent with the contemporary definitions used in early AD in clinical trials; and
* Biomarker confirmation of AD pathology, demonstrated by a positive plasma phosphorylated tau-217 (p-tau217) result according to the 2024 National Institute on Aging-Alzheimer's Association (NIA-AA) diagnostic guidelines.
Exclusion Criteria:
* Exclusion criteria include evidence of other neurological, psychiatric, or systemic conditions that could cause cognitive and functional impairments (e.g., substantial concomitant cerebrovascular disease, alcoholism, certain medications that could have a substantial effect on cognition, untreated major depressive disorder, and heart, renal or hepatic failure).
* Individuals who have contraindications to receiving rTMS, including a history of seizures or any non-removable metal in their heads or within 12 inches of the TMS coil will be excluded.
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