Zenagamtide vs Semaglutide for Weight Loss

A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

Recruiting Phase 3 Interventional Study
Overweight Obesity
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Pivotal Trial This treatment is in the last trial phase before FDA approval. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 3
Study type
Interventional
Purpose
Treatment
Participants needed
650 (estimated)
Sponsor
Novo Nordisk A/S · Industry
Who this trial is looking for

This trial is looking for adults who are overweight or obese to test how well a new medicine, zenagamtide, helps with weight loss compared to another medicine called semaglutide. Participants will need to meet certain health requirements to join.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am 18 years old or older
  • I am male or female (sex at birth)

You may not be able to join if

  • I have a glycated hemoglobin (HbA1c) level of 6.5% or higher
  • I have a history of type 1 or type 2 diabetes
  • I have taken glucagon-like-peptide-1 (GLP-1) medications in the past year

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

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About This Trial

The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Male or female (sex at birth). * Age 18 years or above at the time of signing the informed consent. Exclusion Criteria: * Glycated haemoglobin (HbA1c) ≥ 6.5% (48 millimoles per mole \[mmol/mol\]) as measured by the central laboratory at screening. * History of type 1 or type…
Contacts

Novo Nordisk

(+1) 866-867-7178

clinicaltrials@novonordisk.com

CONTACT