Influence of Early Wound Healing on the Outcomes of Regenerative Periodontal Surgery
Recruiting
Observational Study
Intrabony Periodontal DefectWound Healing
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
100 (estimated)
Sponsor
University of Roma La Sapienza · Other
Who this trial is looking for
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This study investigates whether early post-surgical healing (1-2 weeks) affects the 12-month clinical and radiographic success of periodontal regenerative therapy, and identifies patient-related, site-specific, and technique-related factors associated with optimal early wound healing, in patients with Stage III-IV periodontitis.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Diagnosis of Stage III or IV Periodontitis.
* Presence of at least one deep interproximal infrabony defect (Probing Pocket Depth \[PPD\] \>= 6 mm, radiographic depth \>= 3 mm).
* Optimal oral hygiene: Full-Mouth Plaque Score (FMPS) and Full-Mouth Bleeding Score (FMBS) \< 15% a…
Inclusion Criteria:
* Diagnosis of Stage III or IV Periodontitis.
* Presence of at least one deep interproximal infrabony defect (Probing Pocket Depth \[PPD\] \>= 6 mm, radiographic depth \>= 3 mm).
* Optimal oral hygiene: Full-Mouth Plaque Score (FMPS) and Full-Mouth Bleeding Score (FMBS) \< 15% at the time of surgery.
Exclusion Criteria:
* Systemic: ASA III-VI classification; uncontrolled diabetes; medications causing gingival overgrowth (e.g., nifedipine, cyclosporine, phenytoin); heavy smokers (\>10 cigarettes/day); pregnancy or lactation.
* Local: Third molars; Grade III tooth mobility; inadequate endodontic treatment; teeth undergoing orthodontic treatment; teeth supporting removable or implant-linked fixed prosthetics.
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