Alpha-Lipoic Acid for Women with Infertility Issues
Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age
Recruiting
N/A
Interventional Study
Female Infertility Due to Diminished Ovarian Reserve
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 35 – 45
- Sex
- Female
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 60 (estimated)
- Sponsor
- Kaohsiung Veterans General Hospital. · Other
Who this trial is looking for
This trial is looking for women aged 35-45 who are having difficulty getting pregnant. Participants will take a supplement called alpha-lipoic acid for two months before their IVF treatment or go directly to IVF without the supplement.
Are You a Good Fit for This Trial?
You may be able to join if
- I am aged 35-45 years
- I have a BMI between 18 and 35
- I plan to undergo IVF using my own eggs
You may not be able to join if
- I have primary ovarian insufficiency
- My partner has azoospermia or severe infertility
- I have a congenital uterine anomaly
- I have severe intrauterine adhesion
- I or my partner have a known chromosomal anomaly
- I have been diagnosed with cancer
- I am using donor eggs
- I am allergic to alpha-lipoic acid
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Female fertility declines with advancing age, largely because of deteriorating oocyte quality driven by mitochondrial dysfunction and oxidative stress within the ovarian microenvironment. Alpha-lipoic acid (ALA) is a potent antioxidant that crosses cell and mitochondrial membranes, regenerates other antioxidants (vitamin C, vitamin E, glutathione, coenzyme Q10), and supports mitochondrial respirat…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 35-45 years
* BMI 18-35 kg/m²
* Planning to undergo IVF treatment using own oocytes
Exclusion Criteria:
* Primary ovarian insufficiency
* Azoospermia or severe male-factor infertility in the partner
* Congenital uterine anomaly
* Severe intrauterine adhesion
* Known chro…
Contacts