Maternal Inheritance of a Pathogenic MT-ND1 Mutation Causes Mitochondrial Dysfunction and Spermatogenic Failure in Men
Recruiting
Observational Study
Azoospermia, Nonobstructive
Cryptozoospermia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Sex
- Any
- Study type
- Observational
- Participants needed
- 1,200 (estimated)
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University · Other
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About This Trial
Idiopathic non-obstructive azoospermia and cryptozoospermia are severe forms of male infertility in which sperm production is absent or extremely low and the cause is often unknown. This retrospective observational study examined whether mitochondrial DNA variants, particularly the MT-ND1 m.3700G\>A variant, are associated with impaired sperm production in Chinese men.
Existing clinical records a…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Men with idiopathic non-obstructive azoospermia or cryptozoospermia.
* Male patients undergoing a clinically indicated testicular biopsy, testicular sperm aspiration (TESA), microdissection testicular sperm extraction (micro-TESE), or a related clinical procedure, when residua…
Contacts