Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use
Recruiting
N/A
Interventional Study
Nicotine Dependence
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 21 – 55
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 45 (estimated)
- Sponsor
- University of Southern California · Other
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About This Trial
Oral nicotine pouches (ONPs) are non-combustible nicotine products that may reduce cigarette craving and smoking cue-induced brain activity, supporting their potential as harm-reduction tools for adults who smoke cigarettes. This within-subject, repeated-measures study will evaluate the acute effects of a single 6 mg oral nicotine pouch on subjective craving and prefrontal neural responses to smok…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 21 years - 55 years
* Self-reported use of cigarettes within the past 30 days
* Biochemical confirmation of cigarette use:
o Carbon monoxide (CO) breath sample ≥10 ppm
* Fagerström Test for Nicotine Dependence (FTND) score ≥5, indicating moderate to high nicotine depend…
Contacts