More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)
Recruiting
N/AInterventional Study
Acute Lymphatic LeukemiaLymphoma
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
3 and older
Sex
Any
Study type
Interventional
Purpose
Diagnostic
Participants needed
180 (estimated)
Sponsor
University of Erlangen-Nürnberg Medical School · Other
Who this trial is looking for
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In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls. Modern imaging techniques (MRI, MSOT, and echocardiography) as well as questionnaires assessing cardiopulmonary and mental health are used.
Trial Locations
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Eligibility Criteria
Control Group:
Inclusion Criteria:
* no cancer diagnosis
* no lung diseases
* no vascular diseases
* No subjective reduction in physical performance
* age \>/= 18 years
Exclusion Criteria:
* Pregnancy, Lactation
* Known pleural or pericardial effusion
* Critical condition (requiring respiratory …
Control Group:
Inclusion Criteria:
* no cancer diagnosis
* no lung diseases
* no vascular diseases
* No subjective reduction in physical performance
* age \>/= 18 years
Exclusion Criteria:
* Pregnancy, Lactation
* Known pleural or pericardial effusion
* Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure)
* Marked thoracic deformities/malformations
* Previous lung surgery
* Injuries that do not allow physical stress diagnostics
* Rejection of MRI imaging
* General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.)
Survivors of ALL:
Inclusion Criteria:
* Completed therapy for ALL
* age \>/= 3 years
Exclusion Criteria:
* Pregnancy, Lactation
* Known pleural or pericardial effusion
* Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure)
* Marked thoracic deformities/malformations
* Previous lung surgery
* Injuries that do not allow physical stress diagnostics
* Rejection of MRI imaging
* General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.)
Survivors of Lymphoma:
Inclusion Criteria:
* Completed therapy for lymphoma
* age \>/= 3 years
Exclusion Criteria:
* Pregnancy, Lactation
* Known pleural or pericardial effusion
* Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure)
* Marked thoracic deformities/malformations
* Previous lung surgery
* Injuries that do not allow physical stress diagnostics
* Rejection of MRI imaging
* General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.)
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