Treating Contact Lens Discomfort With Varenicline Solution Nasal Spray 0.03mg

Inclusion Criteria: * Adult male and female subjects of any race or ethnicity who are ≥18 years of age. * Best corrected CL visual acuity of 0.3 Logarithm of the Minimum Angle of Resolution (logMAR) or better in both eyes (Snellen equivalent 20/40). * Soft 1-day silicone hydrogel CL wearer (daily disposable only) * Contact Lens Dry Eye Questionnaire (CLDEQ)-8 scores (CLDEQ-8 scores ≥ 12).16 * A VAS score of ≥40 for Eye Dryness and End of Day Contact Lens Discomfort;18, 19 * A corneal fluorescein staining on the original NEI scale of ≥3. * Habitually wears soft CLs for a minimum of 5 days per week for 6 hours per day during the month prior to enrollment.20 * Willing to maintain habitual CL wear routine for the 3 months duration of the study.20 * Willing to only use Tyrvaya nasal spray prescription dry eye treatment for the 3 months duration of the study. * Willing to not use any lipid containing artificial tear (AT) for the 3 months duration of the study. * Willing to only use non-lipid containing preservative free artificial tear for the 3 months duration of the study if needed, but no more than 4 times per day; also must agree to record frequency of daily AT use if applicable. * Willing to record daily time for CL application, removal, and Tyrvaya applications. * Habitual CLs have an acceptable fit (good centration, movement, and coverage Exclusion Criteria: * Any history of Tyrvaya use within six months of enrollment * Are currently an overnight CL wearer. * Are currently wearing rigid gas permeable CLs, scleral CL, hybrid CLs, or reusable soft CLs. * Have known systemic health conditions that are known to alter tear film physiology (e.g., primary and secondary Sjögren's syndrome). * Have a history of ocular surgery within the past 12 months. * Have a history of viral eye disease. * Have a history of severe ocular trauma, active ocular infection or inflammation. * Have ever used using isotretinoin-derivates (e.g., Accutane). * Are currently taking ocular medications or plan to during the study (e.g., DED, glaucoma, etc). * Subjects with meibomian gland blockage or significant atrophy (e.g., severe MGD). Currently having \>50% blockage of Meibomian glands in more than two eyelids * Having blepharitis and/or demodex blepharitis \> grade 1 * Have had a physical meibomian gland dysfunction treatment withing three months of enrollment (iLux, Lipiflow, Radio Frequency and IPL with manual expressions, microblepharoexfoliation etc.). * Have used a prescription DED or ocular surface disease medication in the last 1 month. * Have a condition or in a situation, which in the examiner's opinion, may put the subject at significant risk, may confound the study results, or may significantly interfere with their participation. * Are pregnant or breast feeding or plan to get pregnant. * Are a student, employee, or relative of the study team.