Adequacy of Haemodiafiltration: Middle Molecules Clearance, Patients Reported Outcomes and Sodium Balance
Recruiting
Observational Study
Haemodiafiltration
Haemodialysis
Patient Reported Outcome Measurements
Nutrition
Malnutrition (Calorie)
Fluid Balance Outcomes
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 300 (estimated)
- Sponsor
- East and North Hertfordshire NHS Trust · Government
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About This Trial
The goal of this observational study is to understand the differences in terms of middle molecules clearance and patient outcomes in High (\>23Litres (L)) vs Low (\<23 L) convection volume (CV) Hemodiafiltration (HDF) and to understand the effect of dialysate fluid sodium concentration (137 vs 140 mmol/L) on overhydration volume in patients on HD and HDF.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 18 years or above.
* Ability to give informed consent.
* End stage kidney disease (ESKD) treated by haemodialysis for at least 3 months.
* Prognosis \> 6 months as assessed by principal investigator (PI)
Contacts