No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 70
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Basic Science
Participants needed
120 (estimated)
Sponsor
Pfizer · Industry
Who this trial is looking for
This trial is looking for adults with obesity to see how well they can tolerate different doses of a study medicine called PF-08642534. Participants will go through a screening to ensure they meet the health requirements before joining the study.
Are You a Good Fit for This Trial?
You may be able to join if
I have a body mass index (BMI) between 30.0 and 40.0
I have stable body weight before the study
I am generally healthy but may have mild chronic conditions
You may not be able to join if
I have diabetes
I have significant heart problems
I have liver problems
I have kidney problems
I have gastrointestinal disorders
I have psychiatric disorders
I have conditions that affect drug absorption or metabolism
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study will look at a study drug called PF-08642534 in people with obesity (have too much body weight) to see: if participants can take different amounts (doses) of the study drug in a safe way and how adults with obesity tolerate it, and how the body handles the study drug (for example, how the study drug is absorbed and removed from the body).
People who want to join the study will first go…
This study will look at a study drug called PF-08642534 in people with obesity (have too much body weight) to see: if participants can take different amounts (doses) of the study drug in a safe way and how adults with obesity tolerate it, and how the body handles the study drug (for example, how the study drug is absorbed and removed from the body).
People who want to join the study will first go through a screening period of up to 4 weeks. Doctors will check if each person meets the study conditions, including age, body weight, and general health. People with certain medical conditions will not be able to take part in the study.
Trial Locations
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Eligibility Criteria
Inclusion:
* Body mass index (BMI) ≥30.0 and ≤40.0 kg/m², and with stable body weight prior to screening.
* Participants are generally otherwise healthy but may have mild chronic conditions (eg, dyslipidemia or hypertension)
Exclusion:
\- Individuals with diabetes, significant cardiovascular, hep…
Inclusion:
* Body mass index (BMI) ≥30.0 and ≤40.0 kg/m², and with stable body weight prior to screening.
* Participants are generally otherwise healthy but may have mild chronic conditions (eg, dyslipidemia or hypertension)
Exclusion:
\- Individuals with diabetes, significant cardiovascular, hepatic, renal, gastrointestinal, or psychiatric disorders, or conditions that may affect drug absorption or metabolism, are not eligible to participate.
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