Understanding and Enhancing Human Health and Movement
Recruiting
N/AInterventional Study
Spinal Cord InjuryStroke (CVA) or Transient Ischemic AttackMultiple Sclerosis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
75 (estimated)
Sponsor
Louis Stokes VA Medical Center · Federal
Who this trial is looking for
This trial is looking for adults with paralysis due to conditions like multiple sclerosis, spinal cord injury, or stroke. Participants will help researchers understand how electrical stimulation can improve movement and function.
Are You a Good Fit for This Trial?
You may be able to join if
I am over 18 years old.
I have paralysis that affects my trunk or legs.
I can move my legs and trunk muscles.
I have good social support.
I am willing to attend follow-up appointments.
My injury happened more than six months ago.
My height and weight fit within the study's limits.
A doctor says my condition is stable.
You may not be able to join if
I do not speak English.
I am pregnant.
I have current pressure sores.
I have serious joint issues that prevent movement.
I have a history of broken bones or very low bone density.
I have balance problems or have fallen recently.
I have untreated orthopedic issues like a fracture.
I have serious ongoing health issues that could be worsened by this study.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
By doing this study, investigators hope to learn how electrical stimulation can improve human movement, biomechanics, and function and to gather information on the safety and effectiveness of an implanted electrical stimulation system after paralysis from spinal cord injury, stroke, multiple sclerosis, and traumatic brain injury.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Skeletal maturity and ability to sign informed consent (\>18 years)
* Non-ventilator dependent paralysis resulting from injuries such as: mid cervical/thoracic (C4 or below) spinal cord injuries, poststroke hemiparesis, TBI, or MS, affecting the trunk and/or lower limbs
* Inne…
Inclusion Criteria:
* Skeletal maturity and ability to sign informed consent (\>18 years)
* Non-ventilator dependent paralysis resulting from injuries such as: mid cervical/thoracic (C4 or below) spinal cord injuries, poststroke hemiparesis, TBI, or MS, affecting the trunk and/or lower limbs
* Innervated and excitable lower extremity and trunk musculature
* Adequate social support and stability
* Willingness to comply with follow-up procedures
* Time post injury greater than six months
* Appropriate body habitus (height and weight within acceptable limits as determined by study physician)
* Neurologically stable as determined by a physician
Exclusion Criteria:
* Non-English speaking
* Females who are pregnant
* Current pressure injuries that would be exacerbated by study activities
* Severe contractures or uncontrolled spasticity of any major joint of the upper or lower extremities that results in a fixed deformity that would interfere with study activities
* History of spontaneous fractures or other evidence of excessively low bone density
* History of vestibular dysfunction, balance problems, or spontaneous falls
* Acute and or/untreated orthopedic problems that would prevent a participant from weight bearing or exercising such as a dislocation or fracture.
* Acute and/or chronic problems left untreated or not controlled that would put a participant at risk by using stimulation such as cardiac abnormalities, immunological/pulmonary/renal/circulatory compromise, diabetes or hypertension
* Presence of a demand pacemaker or cardiac defibrillator
* Any other medical or psychological condition that would be a contraindication
* Current pressure ulcers
* Significant range of motion limitations that would compromise study activities
* Body habitus that would compromise study activities
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