No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
40 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
140 (estimated)
Sponsor
University of Chicago · Other
Who this trial is looking for
This trial is looking for people with knee arthritis on the inside of their knee. Participants will receive a steroid injection either on the inside or outside of their knee and answer some pain surveys at different times after the injection.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 40 years old.
I have been diagnosed with knee osteoarthritis mainly affecting the inside of my knee.
I have moderate to severe knee osteoarthritis as shown in X-rays.
I am preparing to receive a steroid injection in my knee as part of my treatment.
I can provide consent to participate.
I can complete follow-up surveys in English.
You may not be able to join if
I have knee osteoarthritis mainly affecting the outside of my knee.
I have inflammatory arthritis, like rheumatoid arthritis or gout.
I have a suspected or confirmed infection in my knee.
I have had knee replacement surgery on the knee being treated.
I have surgery planned for my knee within the next 12 weeks.
I cannot complete follow-up assessments.
I have another reason determined by a doctor that would prevent me from participating.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:
1. Be randomly divided into getting their steroid injection on the inside or outside of their knee.
2. Answer a pain survey before their injection as well…
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:
1. Be randomly divided into getting their steroid injection on the inside or outside of their knee.
2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.
Trial Locations
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City
State
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Status
Eligibility Criteria
Inclusion Criteria:
* Age ≥ 40
* Clinical diagnosis of knee OA with predominant medial compartment symptoms
* Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
* Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless o…
Inclusion Criteria:
* Age ≥ 40
* Clinical diagnosis of knee OA with predominant medial compartment symptoms
* Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
* Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
* Able to provide informed consent
* Able to complete phone, email, or MyChart follow-ups in English
Exclusion Criteria:
* Predominant lateral compartment OA or patellofemoral-only OA
* Inflammatory arthritis (RA, gout flare, etc.)
* Suspected or confirmed joint infection or overlying cellulitis
* Prior knee arthroplasty on the index knee
* Planned surgery for index knee within 12-week follow-up
* Inability to complete follow-up assessments
* Other clinician-determined contraindication to CSI
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