A Phase 3 Trial of Inhaled Mosliciguat in PH-ILD (PHrontier)

Inclusion Criteria: * Participants willing and able to provide informed consent. * Participants with diagnosis of pulmonary hypertension (PH) associated with interstitial lung disease (ILD). Diagnosis will be confirmed by a high-resolution computerized tomography (HR-CT) scan showing diffuse parenchymal disease. Eligible diagnosed disease include: 1. Idiopathic interstitial pneumonia (IIP) 2. Chronic Hypersensitivity pneumonitis 3. ILD associated connective tissue disease (CTD) * Confirmed pulmonary hypertension by right heart catheterization (RHC). * Ability to perform 6-minute walk distance ≥100 meters. Exclusion Criteria: * Diagnosis of PH Group 1 (eg, pulmonary arterial hypertension), Group 2 (related to left heart disease), Group 4 (eg, chronic thromboembolic pulmonary hypertension), or Group 5 (eg, unclassified). * Exacerbation of underlying lung disease requiring change in therapy or hospitalization within 28 days prior to randomization * Receiving \>10 L/min oxygen supplementation by any mode of delivery at rest * History of intolerance to mosliciguat, or sGC stimulators or activators. * Initiation of pulmonary rehabilitation or ongoing acute phase of rehabilitation within 28 days prior to randomization. * Receipt of investigational or interventional therapy within 42 days OR 5 half-lives (whichever is longer) prior to randomization.