Inhaled Treprostinil for Exercise-Induced Pulmonary Hypertension
Early Intervention With Inhaled Treprostinil Among Patients With Exercise-Induced Pulmonary Hypertension (EPIH)
Recruiting
Early Phase 1Interventional Study
Pulmonary Hypertension
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
32 (estimated)
Sponsor
Valley Health System · Other
Who this trial is looking for
This trial is looking for adults with specific lung or connective tissue diseases who experience high blood pressure in their lungs during exercise. Participants will either receive inhaled treprostinil along with regular care or just the regular care for up to 12 months.
Are You a Good Fit for This Trial?
You may be able to join if
I am 18 years or older
I have been diagnosed with interstitial lung disease or a connective tissue disease
I am in WHO Functional Class II or III
I have resting pulmonary vascular resistance within certain limits
I have exercise-induced pulmonary hypertension
I can provide informed consent
You may not be able to join if
I have resting pulmonary hypertension
I have significant left heart disease
I have chronic thromboembolic pulmonary hypertension
I had an acute pulmonary embolism in the past 6 months
I am currently on targeted therapy for pulmonary arterial hypertension
I am pregnant or breastfeeding
I have severe kidney or liver problems
I cannot perform exercise testing
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This prospective open-label matched-control pilot study evaluates whether inhaled treprostinil improves exercise pulmonary vascular resistance and functional outcomes in adults with interstitial lung disease or connective tissue disease and exercise-induced pulmonary hypertension. Participants will receive inhaled treprostinil plus standard care or standard care alone and will be followed for 6 mo…
This prospective open-label matched-control pilot study evaluates whether inhaled treprostinil improves exercise pulmonary vascular resistance and functional outcomes in adults with interstitial lung disease or connective tissue disease and exercise-induced pulmonary hypertension. Participants will receive inhaled treprostinil plus standard care or standard care alone and will be followed for 6 months, with an optional extension to 12 months.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age ≥18 years
* ILD diagnosis or CTD diagnosis
* WHO Functional Class II-III
* Resting RHC:
* mPAP ≤20 mmHg
* PVR ≤2 WU
* PAWP ≤15 mmHg
* Exercise-induced pulmonary hypertension on iCPET
* Able to provide informed consent
Exclusion Criteria:
* Resting pulmonary hypert…
Inclusion Criteria:
* Age ≥18 years
* ILD diagnosis or CTD diagnosis
* WHO Functional Class II-III
* Resting RHC:
* mPAP ≤20 mmHg
* PVR ≤2 WU
* PAWP ≤15 mmHg
* Exercise-induced pulmonary hypertension on iCPET
* Able to provide informed consent
Exclusion Criteria:
* Resting pulmonary hypertension
* Significant left heart disease
* CTEPH
* Acute PE within 6 months
* Current PAH-targeted therapy
* Pregnancy or breastfeeding
* Severe renal or hepatic impairment
* Inability to perform exercise testing
* Contraindication to RHC
* Treprostinil hypersensitivity
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