ALV-100 for Weight Maintenance in Overweight Adults

Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight Loss

Recruiting Phase 2 Interventional Study
Overweight , Obesity Adults
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 75
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
220 (estimated)
Sponsor
Alveus Therapeutics, Inc. · Industry
Who this trial is looking for

This trial is looking for adults who have lost weight using a treatment called semaglutide. Participants will help assess the safety and effectiveness of a new medication called ALV-100 while maintaining their current weight loss and lifestyle.

Are You a Good Fit for This Trial?
Must be taking Semaglutide

You may be able to join if

  • I am an adult aged 18 to 75.
  • I have a BMI of 27 or more.
  • I have been on semaglutide for weight management for at least 3 months.
  • I have lost at least 10% of my body weight on semaglutide.
  • I have maintained my body weight for at least 3 months.
  • I am willing to stick to my current diet and exercise plan.

You may not be able to join if

  • I have a history of Type 1 or Type 2 diabetes.
  • I have had surgery or a device for weight loss.
  • My obesity is caused by a medical disorder.
  • I have taken medications that may cause significant weight gain in the last 3 months.
  • I have a family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2.
  • I have had cancer in the last 5 years.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

A study of ALV-100 to assess efficacy, safety and tolerability among participants with overweight or obesity who have previously achieved a body weight reduction of ≥10% while treated with incretin-based therapies.

Trial Locations
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Eligibility Criteria
Key inclusion criteria 1. Adult male and female participants, aged ≥18 to ≤75 2. BMI ≥27 kg/m2 at screening. 3. Has been treated with incretin-based therapy for weight management at a stable dose for at least 3 continuous months prior to screening. 4. Tolerating incretin-based therapy at the discre…
Contacts

Study Director

+1 215-607-2243

clinicaltrials@alveustx.com

CONTACT