Study for Alzheimer's Disease Risk in Family Members
Dominantly Inherited Alzheimer Network (DIAN)
Recruiting
Observational Study
Alzheimer's Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
700 (estimated)
Sponsor
Washington University School of Medicine · Other
Who this trial is looking for
This trial is looking for adults who are children of someone with Alzheimer's disease and have not shown symptoms themselves. Participants will help researchers find signs that might predict who will develop Alzheimer's disease in the future.
Are You a Good Fit for This Trial?
You may be able to join if
I have a parent with Alzheimer's disease.
I am 18 years old or older.
I have no symptoms or only mild cognitive impairment.
I can provide two people who can share information about me.
I can understand language at about a 6th grade level or higher.
You may not be able to join if
I am under age 18.
I have a serious medical or mental health issue that makes it hard to take part.
I need nursing home care.
I do not have anyone who can help provide information for the study.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Written informed consent obtained from participant and collateral source prior to any study-related procedures.
* Aged 18 (inclusive) or older and the child of an affected individual (clinically or by testing) in a pedigree with a known mutation for ADAD.
* Cognitively normal …
Inclusion Criteria:
* Written informed consent obtained from participant and collateral source prior to any study-related procedures.
* Aged 18 (inclusive) or older and the child of an affected individual (clinically or by testing) in a pedigree with a known mutation for ADAD.
* Cognitively normal to very mild or mild cognitive impairment (CDR score range 0-1.0). Primary enrollment will focus on the recruitment of asymptomatic adult children who are more than 15 years younger than the estimated age of symptom onset. Enrollment of new participants with moderate cognitive impairment is allowed with the prior approval of the DIAN Coordinating Center.
* Has two persons who are not their full-blooded siblings who can serve as collateral sources for the study.
* Fluent in a language approved by the DIAN Coordinating Center at about the 6th grade level (international equivalent) or above.
Exclusion Criteria:
* Under age 18
* Medical or psychiatric illness that would interfere in completing initial and follow-up visits
* Requires nursing home level care
* Has no one who can serve as a study informant
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