No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 59
Sex
Any
Trial phase
Phase 3
Study type
Interventional
Purpose
Treatment
Participants needed
29 (estimated)
Sponsor
Montana State University · Other
Who this trial is looking for
This trial is looking for people who use methamphetamine and have depression and anxiety. Participants will take creatine to see if it helps their mood and use of methamphetamine.
Are You a Good Fit for This Trial?
You may be able to join if
I use methamphetamine as my main drug
I have been diagnosed with major depressive disorder
I have been diagnosed with an anxiety disorder
I have a Hamilton Depression Rating Scale score of 16 or higher
I have a Hamilton Anxiety Scale score of 18 or higher
I have been stable on my mood medications for at least 4 weeks
You may not be able to join if
I cannot give informed consent
I am at significant risk of suicide or harming others
I have a substance-related diagnosis other than methamphetamine dependence
I am pregnant
I have a history of kidney disease
I have a significant medical or neurological illness
I have had a hypersensitivity reaction to creatine
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
* Assess the antidepressant/anxiolytic effect of creatine in male and female methamphetamine users
* Assess creatine's effect on methamphetamine use
* Assess the safety of creatine in male methamphetamine users with depression
Trial Locations
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City
State
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Status
Eligibility Criteria
Inclusion Criteria:
* Current primary diagnosis of methamphetamine dependence or abuse, with methamphetamine preferred drug of abuse
* Current diagnosis of major depressive disorder (primary or substance-induced)
* Current diagnosis of an anxiety disorder (primary or substance-induced)
* Current Ha…
Inclusion Criteria:
* Current primary diagnosis of methamphetamine dependence or abuse, with methamphetamine preferred drug of abuse
* Current diagnosis of major depressive disorder (primary or substance-induced)
* Current diagnosis of an anxiety disorder (primary or substance-induced)
* Current Hamilton Depression Rating scale score \> or = to 16
* Current Hamilton Anxiety Scale score \> = to 18
* If taking a psychotropic medication for depressed or anxious mood, regimen must be stable for \> = to 4 weeks prior to creatine treatment initiation
Exclusion Criteria:
* Persons unable to provide adequate informed consent
* Persons who are at clinically significant suicidal or homicidal risk
* Primary substance-related diagnosis other than methamphetamine dependence or abuse
* Positive pregnancy test (females only)
* History of renal disease
* Clinically significant medical or neurological illness identified by history, physical exam and laboratory testing
* History of hypersensitivity reaction to creatine
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