No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 75
Sex
Any
Study type
Observational
Participants needed
350 (estimated)
Sponsor
University of California, San Francisco · Other
Who this trial is looking for
This trial is looking for healthy adults aged 18-75 or those with type 2 diabetes or metabolic syndrome. Participants will be asked to provide some health information and biological samples.
Are You a Good Fit for This Trial?
Rules you outChronic kidney diseaseAutoimmune diseaseSevere heart problemsSignificant liver diseaseHistory of organ transplantPoorly controlled asthmaPregnancy or breastfeeding
You may be able to join if
I am between 18 and 75 years old.
I have been diagnosed with type 2 diabetes.
I have been diagnosed with metabolic syndrome.
I am a healthy individual.
You may not be able to join if
I have chronic kidney disease.
I have an autoimmune or inflammatory disease.
I have had unstable angina or heart problems in the last 3 months.
I have significant liver disease.
I weigh more than 450 pounds.
I have had an organ transplant.
I have poorly controlled asthma.
I am pregnant or breastfeeding.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Obesity affects over one third of US adults (\>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is associated with increased mortality through its linkage to comorbidities including diabetes, hypertension, dyslipidemia, osteoarthritis, sleep apnea and psychosocial disturbances. Given its prevalence, impact on morbidity an…
Obesity affects over one third of US adults (\>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is associated with increased mortality through its linkage to comorbidities including diabetes, hypertension, dyslipidemia, osteoarthritis, sleep apnea and psychosocial disturbances. Given its prevalence, impact on morbidity and mortality, and economic cost, limiting the spread of obesity and its consequences is one of the most important problems of our time.
In this proposed study, investigators will recruit participants from a wide range of body mass index (BMI), ethnicity and Diabetes risk to collect data and blood, stool and adipose tissue samples in the San Francisco bay area.
Trial Locations
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City
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Status
Eligibility Criteria
Inclusion Criteria:
* Participants will be healthy individuals between the ages of 18-75 years. These cutoffs are designed to allow inclusion of postmenopausal women, and younger/more active patients who are increasingly undergoing bariatric surgery.
* Patients with either diabetes type 2 or the me…
Inclusion Criteria:
* Participants will be healthy individuals between the ages of 18-75 years. These cutoffs are designed to allow inclusion of postmenopausal women, and younger/more active patients who are increasingly undergoing bariatric surgery.
* Patients with either diabetes type 2 or the metabolic syndrome will be included in the cohort.
Exclusion Criteria:
* Participants with chronic kidney disease (\> stage 4)
* Autoimmune/inflammatory disease (e.g., Lupus, Ulcerative Colitis, etc.)
* Unstable angina, New York (NY) class III or IV congestive heart failure or myocardial infarction within 3 months of entry
* Clinically significant liver disease (e.g. Cirrhosis or liver failure)
* Weight \> 450 pounds (DXA scan weight limit)
* History of organ transplant
* Treatment with chemotherapy or radiation therapy at the time of enrollment in study.
* Poorly controlled asthma (participants requiring inhaled glucocorticoids and/or oral glucocorticoids)
* Current nasal corticosteroid use (within the past month)
* Excessive alcohol or substance abuse
* Current use of anabolic steroids or testosterone for bodybuilding purposes. Testosterone use is permitted if prescribed for hypogonadism and dose stable for the past 6 months.
* Patients actively enrolled in interventional trials involving investigational agents
* Pregnant or breast-feeding women
* Appears unlikely or unable to participate in the required study procedures as assessed by the investigator, study coordinator or designee.
* History of abnormal clotting
* Previous bariatric surgery
* Anticoagulant use
* Methadone medication
Contacts
No contact information available.
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