152 Recruiting Trials

Clinical Trials
for Diabetes in California

152 clinical trials for Diabetes are currently recruiting participants at study sites in California. Study-related care is provided at no cost.

152
Recruiting trials
274
Study sites
92
Cities
76
Industry-sponsored
32
Phase 2
34
Phase 3

Diabetes clinical trials in California: what to expect

Diabetes is one of the largest areas of clinical research, and the trials differ a great deal by type. Type 2 studies most often test new glucose-lowering or weight-reducing medicines, once-weekly insulins, and combinations with GLP-1 drugs, in people whose A1c is above goal on their current treatment. Type 1 studies test automated insulin delivery systems, immune therapies for people recently diagnosed or at high risk, and cell-based approaches. Others focus on the complications: kidney disease, eye disease, nerve pain and foot ulcers.

In California, recruiting diabetes studies are concentrated in Los Angeles, San Diego, San Francisco and Walnut Creek, with sites in 88 other cities. 76 of the 152 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who diabetes trials usually look for

Type 2 trials typically ask for a confirmed diagnosis, an A1c in a stated range (often between 7 and 10.5 percent) and a stable dose of your current medicines for at least a few months. Many exclude recent insulin use, a recent heart attack or stroke, or kidney function below a cut-off. Type 1 trials are often limited by time since diagnosis and by age, and some enroll children and teenagers with a parent's consent.

You do not need to know your A1c or kidney numbers to ask about a trial; the site measures them at screening.

What taking part involves

Screening includes blood work and a review of your history. Medicine trials usually last six months to three years with visits every one to three months, and many provide a glucose monitor and supplies for the duration. Some compare a new drug with a standard one rather than a placebo, so everyone receives active treatment; others include a placebo arm, and the consent form says which. Study drugs, devices, visits and labs are provided at no cost, and most trials pay for time and travel.

Questions worth asking the study team

Whether you would stay on your current medicines; whether there is a placebo group; how often visits are and whether any can be done remotely; and whether your own doctor will receive the results of study labs. If you have type 1 diabetes, ask whether the study uses your own pump or monitor.

Showing 20 of 152 recruiting Diabetes trials in California

Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide
PHASE4 Palo Alto, California +1 sites NCT06657209
This trial is looking for adults with normal-weight type 2 diabetes and healthy adults without diabetes. Participants will take medications to see how they affect fat cells and insulin function.
Recruiting
Dementia and Diabetes Prevention Program
NA Walnut Creek, California NCT04141878
This trial is looking for older adults at risk of dementia and diabetes. Participants will take part in either an exercise program or receive dietary counseling to improve their health over 32 weeks.
Recruiting
Hypoglycemia Prevention in High-Risk Type 2 Diabetes Patients
NA Pleasanton, California NCT06746714
This trial is looking for people with type 2 diabetes who are at risk of severe low blood sugar. Participants will receive support from a clinical pharmacist using new guidelines to help manage their condition safely.
Recruiting
Salud Diabetes: A Pilot Study Comparing Lifestyle Interventions and Real-Time Continuous Glucose Monitoring
NA Santa Barbara, California NCT06999356
This trial is looking for adults with type 2 diabetes and high blood sugar levels. Participants will track their glucose levels using a provided device as they take part in a program focused on nutrition.
Recruiting
Circulating Biomarkers in the Development of Type 1 Diabetes
N/A Duarte, California NCT05505669
This trial is looking for people with type 1 or type 2 diabetes, as well as healthy volunteers. Participants will provide blood samples and undergo a review of their medical records to help understand diabetes better.
Recruiting
CGM Academy for Youth With Type 1 Diabetes
NA Los Angeles, California NCT06408207
This trial is looking for young people aged 8-18 who have type 1 diabetes. Participants will receive specialized online education about managing their diabetes and complete some questionnaires over time.
Recruiting
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
PHASE3 Anniston, Alabama +4 sites NCT07064473
This trial is looking for adults with type 2 diabetes, high blood pressure, and heart disease. Participants will take either the study medication or a placebo daily for up to 4 years.
Recruiting
A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar
PHASE3 Birmingham, Alabama +4 sites NCT07754461
This trial is looking for adults with type 2 diabetes who want to try a new medicine called survodutide to help control their blood sugar levels. Participants will receive either the medicine or a placebo and will continue their usual diabetes treatments over about 14 months with regular check-ins.
Recruiting
A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes
PHASE3 San Diego, California +4 sites NCT07088068
This trial is looking for young people ages 1 to 25 who have recently been diagnosed with stage 3 type 1 diabetes. Participants will receive either teplizumab or a placebo through an IV to see how it affects their blood sugar control over 52 weeks.
Recruiting
A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
PHASE3 Santa Barbara, California +4 sites NCT07222137
This trial is looking for children and adults who are at high risk for type 1 diabetes, meaning they have certain markers in their blood that suggest they might develop the condition soon. To participate, you should be at least 18 pounds in weight and not have any other types of diabetes or serious heart-related issues. They also won't be able to include anyone who has had certain serious infections or health problems.
Recruiting
AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
PHASE3 Escondido, California +4 sites NCT07533175
This trial is looking for people who have excess weight and type 2 diabetes. Participants will receive either the study medication NNC0487-0111 or a placebo shot once a week, decided by chance.
Recruiting
Research Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to Cagrisema
PHASE3 Fountain Valley, California +4 sites NCT07817251
This trial is looking for adults with type 2 diabetes who are currently stable on a specific diabetes injection. Participants will switch to a new treatment called CagriSema for about 6 months to see how well they tolerate it.
Recruiting
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
PHASE3 Covina, California +4 sites NCT07662213
This trial is looking for adults with type 2 diabetes who struggle to manage their condition. Participants will compare the effectiveness of a new drug, elecoglipron, with an existing treatment, semaglutide.
Recruiting
Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
PHASE3 Escondido, California +4 sites NCT07284901
This trial is looking for people with obesity or overweight who also have type 2 diabetes. Participants will receive a weekly injection of ribupatide to see how it affects their weight and blood sugar levels.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
PHASE3 Concord, California +4 sites NCT07662135
This trial is looking for adults with type 2 diabetes and kidney problems. Participants will take either elecoglipron or a placebo while continuing their diabetes medications.
Recruiting
A Safety, Tolerability, and Efficacy Study of VX-880 and VX-017 in Participants With Type 1 Diabetes
PHASE3 Duarte, California +4 sites NCT04786262
This trial is looking for people with Type 1 diabetes who experience severe low blood sugar. Participants will receive an infusion of VX-880 and will need to use a continuous glucose monitor during the study.
Recruiting
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
PHASE3 Lancaster, California +4 sites NCT07797335
This trial is looking for adults with type 2 diabetes who are at high risk for heart problems. Participants will receive injections of either zenagamtide or insulin glargine once a week to see which works better for controlling blood sugar and weight.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus
PHASE3 Lomita, California +4 sites NCT07662044
This trial is looking for adults with type 2 diabetes that is not well controlled. Participants will take elecoglipron alone or with another medication and compare the effects to a placebo.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
PHASE3 Bakersfield, California +4 sites NCT07662109
This trial is looking for adults with Type 2 Diabetes who have been managing their condition for at least three months but still need better control. They're particularly interested in those whose blood sugar levels are in a specific range and who have a body weight that meets certain guidelines. However, they’re not accepting people with certain serious health issues, like a history of severe low blood sugar or specific types of diabetes other than Type 2.
Recruiting

Where the Diabetes studies are in California

  • University of Southern California, Los Angeles7 trials
  • Children's Hospital Los Angeles, Los Angeles6 trials
  • Diablo Clinical Research, Inc., Walnut Creek6 trials
  • Stanford University, Stanford6 trials
  • University of California San Francisco, San Francisco6 trials
  • Ark Clinical Research, Long Beach5 trials

Counts are recruiting studies listing at least one site in California, from ClinicalTrials.gov, refreshed every two days.

Diabetes clinical trials in California: common questions

How many Diabetes clinical trials are recruiting in California?
TrialFinder currently lists 152 recruiting Diabetes clinical trials with study sites in California. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Diabetes clinical trials located in California?
Study sites for the Diabetes trials listed on this page include Palo Alto, Walnut Creek, Pleasanton, Santa Barbara, Duarte, Los Angeles. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Diabetes clinical trial in California?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Diabetes trials in California also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Diabetes clinical trial in California?
Each study sets its own criteria based on age, Diabetes diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a diabetes clinical trial if I am already on medication?
Usually yes. Most type 2 diabetes trials enroll people on metformin or other oral medicines and test a new treatment on top of them; some require a stable dose for a few months first. Trials that exclude insulin or a specific drug say so in their criteria.
Do I need to know my A1c to apply?
No. Trials state an A1c range, but the study site measures it at the screening visit. You only need to know that you have been diagnosed and which type.
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Diabetes clinical trials study new treatments for Type 1, Type 2, and gestational diabetes, including insulin therapies, diet interventions, and islet-cell transplants.

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