Diabetes Trials / Trials in South Carolina
40 Recruiting Trials

Clinical Trials
for Diabetes in South Carolina

40 clinical trials for Diabetes are currently recruiting participants at study sites in South Carolina. Study-related care is provided at no cost.

40
Recruiting trials
50
Study sites
18
Cities
30
Industry-sponsored
8
Phase 2
21
Phase 3

Diabetes clinical trials in South Carolina: what to expect

Diabetes is one of the largest areas of clinical research, and the trials differ a great deal by type. Type 2 studies most often test new glucose-lowering or weight-reducing medicines, once-weekly insulins, and combinations with GLP-1 drugs, in people whose A1c is above goal on their current treatment. Type 1 studies test automated insulin delivery systems, immune therapies for people recently diagnosed or at high risk, and cell-based approaches. Others focus on the complications: kidney disease, eye disease, nerve pain and foot ulcers.

In South Carolina, recruiting diabetes studies are concentrated in Greenville, Columbia, Gaffney and North Charleston, with sites in 14 other cities. 30 of the 40 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who diabetes trials usually look for

Type 2 trials typically ask for a confirmed diagnosis, an A1c in a stated range (often between 7 and 10.5 percent) and a stable dose of your current medicines for at least a few months. Many exclude recent insulin use, a recent heart attack or stroke, or kidney function below a cut-off. Type 1 trials are often limited by time since diagnosis and by age, and some enroll children and teenagers with a parent's consent.

You do not need to know your A1c or kidney numbers to ask about a trial; the site measures them at screening.

What taking part involves

Screening includes blood work and a review of your history. Medicine trials usually last six months to three years with visits every one to three months, and many provide a glucose monitor and supplies for the duration. Some compare a new drug with a standard one rather than a placebo, so everyone receives active treatment; others include a placebo arm, and the consent form says which. Study drugs, devices, visits and labs are provided at no cost, and most trials pay for time and travel.

Questions worth asking the study team

Whether you would stay on your current medicines; whether there is a placebo group; how often visits are and whether any can be done remotely; and whether your own doctor will receive the results of study labs. If you have type 1 diabetes, ask whether the study uses your own pump or monitor.

Showing 20 of 40 recruiting Diabetes trials in South Carolina

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
PHASE3 Anniston, Alabama +4 sites NCT07064473
This trial is looking for adults with type 2 diabetes, high blood pressure, and heart disease. Participants will take either the study medication or a placebo daily for up to 4 years.
Recruiting
A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar
PHASE3 Birmingham, Alabama +4 sites NCT07754461
This trial is looking for adults with type 2 diabetes who want to try a new medicine called survodutide to help control their blood sugar levels. Participants will receive either the medicine or a placebo and will continue their usual diabetes treatments over about 14 months with regular check-ins.
Recruiting
AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
PHASE3 Birmingham, Alabama +4 sites NCT07533175
This trial is looking for people who have excess weight and type 2 diabetes. Participants will receive either the study medication NNC0487-0111 or a placebo shot once a week, decided by chance.
Recruiting
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
PHASE3 Birmingham, Alabama +4 sites NCT07662213
This trial is looking for adults with type 2 diabetes who struggle to manage their condition. Participants will compare the effectiveness of a new drug, elecoglipron, with an existing treatment, semaglutide.
Recruiting
Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
PHASE3 Cullman, Alabama +4 sites NCT07284901
This trial is looking for people with obesity or overweight who also have type 2 diabetes. Participants will receive a weekly injection of ribupatide to see how it affects their weight and blood sugar levels.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
PHASE3 Sun City, Arizona +4 sites NCT07662135
This trial is looking for adults with type 2 diabetes and kidney problems. Participants will take either elecoglipron or a placebo while continuing their diabetes medications.
Recruiting
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
PHASE3 Birmingham, Alabama +4 sites NCT07797335
This trial is looking for adults with type 2 diabetes who are at high risk for heart problems. Participants will receive injections of either zenagamtide or insulin glargine once a week to see which works better for controlling blood sugar and weight.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus
PHASE3 Birmingham, Alabama +4 sites NCT07662044
This trial is looking for adults with type 2 diabetes that is not well controlled. Participants will take elecoglipron alone or with another medication and compare the effects to a placebo.
Recruiting
A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)
PHASE3 Tucson, Arizona +4 sites NCT06739122
This trial is looking for children with Type 2 diabetes to test different doses of a medication called dulaglutide. Participation will last about 8 months and requires being treated with certain diabetes medications.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus on Background Insulin
PHASE3 Little Rock, Arkansas +4 sites NCT07664553
This trial is looking for adults with type 2 diabetes who are already taking insulin and other medications to lower blood sugar. Participants will compare a new treatment called elecoglipron with a placebo to see how effective and safe it is.
Recruiting
A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes
PHASE2 Birmingham, Alabama +4 sites NCT07668388
This trial is looking for people with type 2 diabetes to test a new medicine called UBT251. Participants will receive either UBT251, a placebo, or another medication called semaglutide, chosen at random.
Recruiting
Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)
PHASE2 Chandler, Arizona +4 sites NCT07296484
This trial is looking for adults who are at least 18 years old and have type 2 diabetes that isn’t well controlled. They should have been on stable diabetes medications for a while and show signs of high cortisol levels. However, it won't include anyone who just started having diabetes, has serious low blood sugar issues, or works night shifts regularly.
Recruiting
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
PHASE2 Birmingham, Alabama +4 sites NCT07340320
This trial is looking for adults with type 2 diabetes who aren't able to control their blood sugar well while taking metformin. Participants will receive either the new medication CX11 or a placebo for 24 weeks, followed by a 2-week follow-up.
Recruiting
DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
PHASE4 Tuscaloosa, Alabama +4 sites NCT06445946
This trial is looking for pregnant women who are at least 18 years old and have been diagnosed with gestational diabetes, needing medication to manage their blood sugar. It’s important that they do not have any serious kidney problems or other specific health conditions that could complicate the study. Women are also excluded if they have certain fetal conditions or previous diabetes issues before pregnancy.
Recruiting
PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes
PHASE4 Huntsville, Alabama +4 sites NCT05390892
This trial is looking for people with type 2 diabetes and heart disease or at high risk for heart disease. Participants will take one of two medications and will be monitored for heart, kidney, and death-related events over time.
Recruiting
CGM for Management of Type 2 Diabetes in Pregnancy
NA Birmingham, Alabama +4 sites NCT06628453
This trial is looking for pregnant women with type 2 diabetes to see if using a continuous glucose monitor is better than checking blood sugar with fingersticks. Participants will monitor their blood sugar, complete surveys, and provide blood samples during the trial.
Recruiting
A Study to Identify and Characterize Patients With Type 2 Diabetes Mellitus for Possible Participation in Ongoing or Future Type 2 Diabetes Mellitus Clinical Studies
N/A Peoria, Arizona +4 sites NCT07606066
This trial is looking for adults with type 2 diabetes who want to participate in future studies. Participants will need to share their health information and follow study procedures.
Recruiting
Specimen and Data Collection in South Carolina Medicaid-Enrolled Patients With Type 2 Diabetes (T2D) and Metabolically Healthy Controls
N/A Orangeburg, South Carolina +1 sites NCT07731399
This trial is looking for South Carolina Medicaid patients aged 40 to 70 with type 2 diabetes and those who are healthy. Participants will provide health data, blood samples, and will receive support from a diabetes educator while also potentially keeping a Fitbit device.
Recruiting
Maturation of Arteriovenous Fistula With Automated Sonography Assessments Trial
NA Dothan, Alabama +4 sites NCT06190717
This trial is looking for adult patients with severe kidney disease who need to create a specific type of access for dialysis. Participants will undergo regular ultrasound assessments to help with the process.
Recruiting
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
NA Chandler, Arizona +4 sites NCT06112418
This trial is looking for older adults with diabetes or risk factors for heart disease. Participants will be randomly assigned to receive different types of care to see which approach is better at preventing heart problems.
Recruiting
See all 40 Diabetes trials in South Carolina

Where the Diabetes studies are in South Carolina

Research sites running the most studies
  • Medical University of South Carolina, Charleston3 trials
  • Research Site, Gaffney3 trials
  • Spartanburg Medical Research, Spartanburg3 trials
  • Trial Management Associates, Myrtle Beach3 trials
  • Accellacare - Mt Pleasant, Mt. Pleasant2 trials
  • Kailera Clinical Site, Spartanburg2 trials
By city

Counts are recruiting studies listing at least one site in South Carolina, from ClinicalTrials.gov, refreshed every two days.

Diabetes clinical trials in South Carolina: common questions

How many Diabetes clinical trials are recruiting in South Carolina?
TrialFinder currently lists 40 recruiting Diabetes clinical trials with study sites in South Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Diabetes clinical trials located in South Carolina?
Study sites for the Diabetes trials listed on this page include Orangeburg. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Diabetes clinical trial in South Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Diabetes trials in South Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Diabetes clinical trial in South Carolina?
Each study sets its own criteria based on age, Diabetes diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a diabetes clinical trial if I am already on medication?
Usually yes. Most type 2 diabetes trials enroll people on metformin or other oral medicines and test a new treatment on top of them; some require a stable dose for a few months first. Trials that exclude insulin or a specific drug say so in their criteria.
Do I need to know my A1c to apply?
No. Trials state an A1c range, but the study site measures it at the screening visit. You only need to know that you have been diagnosed and which type.
Diabetes Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Diabetes Trials

Diabetes clinical trials study new treatments for Type 1, Type 2, and gestational diabetes, including insulin therapies, diet interventions, and islet-cell transplants.

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