54 Recruiting Trials

Clinical Trials
for Diabetes in Tennessee

54 clinical trials for Diabetes are currently recruiting participants at study sites in Tennessee. Study-related care is provided at no cost.

54
Recruiting trials
54
Study sites
12
Cities
34
Industry-sponsored
8
Phase 2
24
Phase 3

Diabetes clinical trials in Tennessee: what to expect

Diabetes is one of the largest areas of clinical research, and the trials differ a great deal by type. Type 2 studies most often test new glucose-lowering or weight-reducing medicines, once-weekly insulins, and combinations with GLP-1 drugs, in people whose A1c is above goal on their current treatment. Type 1 studies test automated insulin delivery systems, immune therapies for people recently diagnosed or at high risk, and cell-based approaches. Others focus on the complications: kidney disease, eye disease, nerve pain and foot ulcers.

In Tennessee, recruiting diabetes studies are concentrated in Nashville, Memphis, Knoxville and Chattanooga, with sites in 8 other cities. 34 of the 54 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who diabetes trials usually look for

Type 2 trials typically ask for a confirmed diagnosis, an A1c in a stated range (often between 7 and 10.5 percent) and a stable dose of your current medicines for at least a few months. Many exclude recent insulin use, a recent heart attack or stroke, or kidney function below a cut-off. Type 1 trials are often limited by time since diagnosis and by age, and some enroll children and teenagers with a parent's consent.

You do not need to know your A1c or kidney numbers to ask about a trial; the site measures them at screening.

What taking part involves

Screening includes blood work and a review of your history. Medicine trials usually last six months to three years with visits every one to three months, and many provide a glucose monitor and supplies for the duration. Some compare a new drug with a standard one rather than a placebo, so everyone receives active treatment; others include a placebo arm, and the consent form says which. Study drugs, devices, visits and labs are provided at no cost, and most trials pay for time and travel.

Questions worth asking the study team

Whether you would stay on your current medicines; whether there is a placebo group; how often visits are and whether any can be done remotely; and whether your own doctor will receive the results of study labs. If you have type 1 diabetes, ask whether the study uses your own pump or monitor.

Showing 20 of 54 recruiting Diabetes trials in Tennessee

Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
EARLY_PHASE1 Nashville, Tennessee NCT06609356
This trial is looking for people with type 1 diabetes or a specific type called GCK-MODY, as well as healthy volunteers. Participants will take a medication that helps lower insulin levels to study its effects on heart and blood sugar health.
Recruiting
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes
PHASE3 New Haven, Connecticut +4 sites NCT07282613
This trial is looking for children and teenagers with type 2 diabetes. Participants will receive either a new medicine called CagriSema or a placebo for part of the study, and then everyone will receive CagriSema for the second part.
Recruiting
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
PHASE3 Anniston, Alabama +4 sites NCT07064473
This trial is looking for adults with type 2 diabetes, high blood pressure, and heart disease. Participants will take either the study medication or a placebo daily for up to 4 years.
Recruiting
A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar
PHASE3 Birmingham, Alabama +4 sites NCT07754461
This trial is looking for adults with type 2 diabetes who want to try a new medicine called survodutide to help control their blood sugar levels. Participants will receive either the medicine or a placebo and will continue their usual diabetes treatments over about 14 months with regular check-ins.
Recruiting
A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes
PHASE3 Scottsdale, Arizona +4 sites NCT07088068
This trial is looking for young people ages 1 to 25 who have recently been diagnosed with stage 3 type 1 diabetes. Participants will receive either teplizumab or a placebo through an IV to see how it affects their blood sugar control over 52 weeks.
Recruiting
AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
PHASE3 Birmingham, Alabama +4 sites NCT07533175
This trial is looking for people who have excess weight and type 2 diabetes. Participants will receive either the study medication NNC0487-0111 or a placebo shot once a week, decided by chance.
Recruiting
Research Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to Cagrisema
PHASE3 Gilbert, Arizona +4 sites NCT07817251
This trial is looking for adults with type 2 diabetes who are currently stable on a specific diabetes injection. Participants will switch to a new treatment called CagriSema for about 6 months to see how well they tolerate it.
Recruiting
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
PHASE3 Birmingham, Alabama +4 sites NCT07662213
This trial is looking for adults with type 2 diabetes who struggle to manage their condition. Participants will compare the effectiveness of a new drug, elecoglipron, with an existing treatment, semaglutide.
Recruiting
Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
PHASE3 Cullman, Alabama +4 sites NCT07284901
This trial is looking for people with obesity or overweight who also have type 2 diabetes. Participants will receive a weekly injection of ribupatide to see how it affects their weight and blood sugar levels.
Recruiting
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
PHASE3 Birmingham, Alabama +4 sites NCT07797335
This trial is looking for adults with type 2 diabetes who are at high risk for heart problems. Participants will receive injections of either zenagamtide or insulin glargine once a week to see which works better for controlling blood sugar and weight.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus
PHASE3 Birmingham, Alabama +4 sites NCT07662044
This trial is looking for adults with type 2 diabetes that is not well controlled. Participants will take elecoglipron alone or with another medication and compare the effects to a placebo.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
PHASE3 Huntsville, Alabama +4 sites NCT07662109
This trial is looking for adults with Type 2 Diabetes who have been managing their condition for at least three months but still need better control. They're particularly interested in those whose blood sugar levels are in a specific range and who have a body weight that meets certain guidelines. However, they’re not accepting people with certain serious health issues, like a history of severe low blood sugar or specific types of diabetes other than Type 2.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus on Background Insulin
PHASE3 Little Rock, Arkansas +4 sites NCT07664553
This trial is looking for adults with type 2 diabetes who are already taking insulin and other medications to lower blood sugar. Participants will compare a new treatment called elecoglipron with a placebo to see how effective and safe it is.
Recruiting
A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes
PHASE2 Birmingham, Alabama +4 sites NCT07668388
This trial is looking for people with type 2 diabetes to test a new medicine called UBT251. Participants will receive either UBT251, a placebo, or another medication called semaglutide, chosen at random.
Recruiting
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
PHASE1 Tucson, Arizona +4 sites NCT06783309
This trial is looking for teenagers and young adults aged 12-35 who have been diagnosed with Type 1 Diabetes in the last 6 months. Participants will take a study medication called CNP-103 and will be monitored for safety and effectiveness over about a year.
Recruiting
A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes
PHASE2 Lancaster, California +4 sites NCT07415954
This trial is looking for adults with type 2 diabetes to test a new medication called NNC0662-0419. Participants will receive either NNC0662-0419, another diabetes medication called semaglutide, or a placebo, to see how well it works and how safe it is.
Recruiting
Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus
PHASE2 San Francisco, California +4 sites NCT07142252
This trial is looking for people recently diagnosed with type 1 diabetes. Participants will take either the study drug or a placebo every two weeks for 26 weeks, followed by a 6-month check-up.
Recruiting
A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes
PHASE2 Birmingham, Alabama +4 sites NCT05762107
This trial is looking for adults with type 1 diabetes who experience low blood sugar at night. Participants will receive either the study drug ZT-01 or a placebo for two weeks while using a glucose monitor to track their blood sugar levels.
Recruiting
PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes
PHASE4 Huntsville, Alabama +4 sites NCT05390892
This trial is looking for people with type 2 diabetes and heart disease or at high risk for heart disease. Participants will take one of two medications and will be monitored for heart, kidney, and death-related events over time.
Recruiting

Where the Diabetes studies are in Tennessee

  • Vanderbilt University Medical Center, Nashville6 trials
  • Vanderbilt University, Nashville4 trials
  • Clinical Research Associates, Nashville3 trials
  • Research Site, Franklin3 trials
  • Research Site, Knoxville3 trials
  • University Diabetes & Endocrine Consultants, Chattanooga3 trials

Counts are recruiting studies listing at least one site in Tennessee, from ClinicalTrials.gov, refreshed every two days.

Diabetes clinical trials in Tennessee: common questions

How many Diabetes clinical trials are recruiting in Tennessee?
TrialFinder currently lists 54 recruiting Diabetes clinical trials with study sites in Tennessee. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Diabetes clinical trials located in Tennessee?
Study sites for the Diabetes trials listed on this page include Nashville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Diabetes clinical trial in Tennessee?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Diabetes trials in Tennessee also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Diabetes clinical trial in Tennessee?
Each study sets its own criteria based on age, Diabetes diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a diabetes clinical trial if I am already on medication?
Usually yes. Most type 2 diabetes trials enroll people on metformin or other oral medicines and test a new treatment on top of them; some require a stable dose for a few months first. Trials that exclude insulin or a specific drug say so in their criteria.
Do I need to know my A1c to apply?
No. Trials state an A1c range, but the study site measures it at the screening visit. You only need to know that you have been diagnosed and which type.
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Diabetes clinical trials study new treatments for Type 1, Type 2, and gestational diabetes, including insulin therapies, diet interventions, and islet-cell transplants.

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