56 Recruiting Trials

Clinical Trials
for Diabetes in Minnesota

56 clinical trials for Diabetes are currently recruiting participants at study sites in Minnesota. Study-related care is provided at no cost.

56
Recruiting trials
34
Study sites
11
Cities
20
Industry-sponsored
10
Phase 2
9
Phase 3

Diabetes clinical trials in Minnesota: what to expect

Diabetes is one of the largest areas of clinical research, and the trials differ a great deal by type. Type 2 studies most often test new glucose-lowering or weight-reducing medicines, once-weekly insulins, and combinations with GLP-1 drugs, in people whose A1c is above goal on their current treatment. Type 1 studies test automated insulin delivery systems, immune therapies for people recently diagnosed or at high risk, and cell-based approaches. Others focus on the complications: kidney disease, eye disease, nerve pain and foot ulcers.

In Minnesota, recruiting diabetes studies are concentrated in Minneapolis, Rochester, Duluth and Mankato, with sites in 7 other cities. 20 of the 56 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who diabetes trials usually look for

Type 2 trials typically ask for a confirmed diagnosis, an A1c in a stated range (often between 7 and 10.5 percent) and a stable dose of your current medicines for at least a few months. Many exclude recent insulin use, a recent heart attack or stroke, or kidney function below a cut-off. Type 1 trials are often limited by time since diagnosis and by age, and some enroll children and teenagers with a parent's consent.

You do not need to know your A1c or kidney numbers to ask about a trial; the site measures them at screening.

What taking part involves

Screening includes blood work and a review of your history. Medicine trials usually last six months to three years with visits every one to three months, and many provide a glucose monitor and supplies for the duration. Some compare a new drug with a standard one rather than a placebo, so everyone receives active treatment; others include a placebo arm, and the consent form says which. Study drugs, devices, visits and labs are provided at no cost, and most trials pay for time and travel.

Questions worth asking the study team

Whether you would stay on your current medicines; whether there is a placebo group; how often visits are and whether any can be done remotely; and whether your own doctor will receive the results of study labs. If you have type 1 diabetes, ask whether the study uses your own pump or monitor.

Showing 20 of 56 recruiting Diabetes trials in Minnesota

The RESET System Pivotal Clinical Trial (Protocol Revision K)
NA Gilbert, Arizona +4 sites NCT04101669
This trial is looking for adults with type 2 diabetes and obesity who are not well controlled on their current medication. Participants will receive treatment with the RESET System along with lifestyle and dietary counseling. They will compare the effects with a group that receives a sham treatment.
Recruiting
A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar
PHASE3 Birmingham, Alabama +4 sites NCT07754461
This trial is looking for adults with type 2 diabetes who want to try a new medicine called survodutide to help control their blood sugar levels. Participants will receive either the medicine or a placebo and will continue their usual diabetes treatments over about 14 months with regular check-ins.
Recruiting
A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes
PHASE3 Scottsdale, Arizona +4 sites NCT07088068
This trial is looking for young people ages 1 to 25 who have recently been diagnosed with stage 3 type 1 diabetes. Participants will receive either teplizumab or a placebo through an IV to see how it affects their blood sugar control over 52 weeks.
Recruiting
AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
PHASE3 Birmingham, Alabama +4 sites NCT07533175
This trial is looking for people who have excess weight and type 2 diabetes. Participants will receive either the study medication NNC0487-0111 or a placebo shot once a week, decided by chance.
Recruiting
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
PHASE3 Birmingham, Alabama +4 sites NCT07662213
This trial is looking for adults with type 2 diabetes who struggle to manage their condition. Participants will compare the effectiveness of a new drug, elecoglipron, with an existing treatment, semaglutide.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
PHASE3 Sun City, Arizona +4 sites NCT07662135
This trial is looking for adults with type 2 diabetes and kidney problems. Participants will take either elecoglipron or a placebo while continuing their diabetes medications.
Recruiting
The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes
PHASE2 Rochester, Minnesota NCT06976619
This trial is looking for people with type 1 or type 2 diabetes who are treated with insulin. Participants will receive a GLP-1 receptor agonist and their islet GLP-1 levels will be studied.
Recruiting
A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes
PHASE1 Los Angeles, California +4 sites NCT07061574
This trial is looking for young people aged 9 to under 21 who have recently been diagnosed with Type 1 Diabetes. Participants will receive a treatment called anti-thymocyte globulin (ATG) followed by either adalimumab or verapamil to see how well it helps preserve insulin secretion over two years.
Recruiting
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
PHASE2 Birmingham, Alabama +4 sites NCT07340320
This trial is looking for adults with type 2 diabetes who aren't able to control their blood sugar well while taking metformin. Participants will receive either the new medication CX11 or a placebo for 24 weeks, followed by a 2-week follow-up.
Recruiting
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
PHASE1 Tucson, Arizona +4 sites NCT06783309
This trial is looking for teenagers and young adults aged 12-35 who have been diagnosed with Type 1 Diabetes in the last 6 months. Participants will take a study medication called CNP-103 and will be monitored for safety and effectiveness over about a year.
Recruiting
Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus
PHASE2 San Francisco, California +4 sites NCT07142252
This trial is looking for people recently diagnosed with type 1 diabetes. Participants will take either the study drug or a placebo every two weeks for 26 weeks, followed by a 6-month check-up.
Recruiting
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
PHASE2 Rochester, Minnesota NCT06967558
This trial is looking for people with prediabetes to understand how a specific treatment affects their blood sugar and insulin function. Participants will receive a treatment that blocks a specific receptor to study its effects.
Recruiting
PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes
PHASE4 Huntsville, Alabama +4 sites NCT05390892
This trial is looking for people with type 2 diabetes and heart disease or at high risk for heart disease. Participants will take one of two medications and will be monitored for heart, kidney, and death-related events over time.
Recruiting
Diabetes in African Youth
PHASE4 Minneapolis, Minnesota NCT05454176
Recruiting
Islet Function in Gestational Diabetes
PHASE1 Rochester, Minnesota NCT07806695
This trial is looking for pregnant individuals who have been screened for gestational diabetes. Participants will help researchers learn how the pancreas works during and after pregnancy by attending study visits.
Recruiting
Insulin and Insulin Pulses During Fasting
NA Rochester, Minnesota NCT06424015
Recruiting
Evaluation of the Fully Closed Loop Omnipod® System in Type 2 Diabetes
NA Los Angeles, California +4 sites NCT07521475
This trial is looking for adults with type 2 diabetes who are currently on insulin therapy. Participants will use the Omnipod® system to manage their diabetes over a 26-week period and may continue using it afterward.
Recruiting
Efficacy of the Omnipod® 6 System Compared With the Omnipod® 5 System
NA Los Angeles, California +4 sites NCT07579702
This trial is looking for people aged 14 to 75 with type 1 or type 2 diabetes who have trouble controlling their blood sugar. Participants will use the Omnipod 6 System to see how well it works compared to the Omnipod 5 System.
Recruiting
Individualized Diabetes Education Assisted by CGM (IDEA-CGM)
NA Minneapolis, Minnesota NCT06784375
This trial is looking for adults with type 2 diabetes. Participants will receive personalized nutrition advice based on their continuous glucose monitor readings.
Recruiting

Where the Diabetes studies are in Minnesota

  • University of Minnesota, Minneapolis16 trials
  • Mayo Clinic in Rochester, Rochester9 trials
  • Mayo Clinic, Rochester6 trials
  • International Diabetes Center, Minneapolis4 trials
  • Essentia Health, Duluth2 trials
  • Research Site, Saint Paul2 trials

Counts are recruiting studies listing at least one site in Minnesota, from ClinicalTrials.gov, refreshed every two days.

Diabetes clinical trials in Minnesota: common questions

How many Diabetes clinical trials are recruiting in Minnesota?
TrialFinder currently lists 56 recruiting Diabetes clinical trials with study sites in Minnesota. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Diabetes clinical trials located in Minnesota?
Study sites for the Diabetes trials listed on this page include Rochester, Minneapolis. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Diabetes clinical trial in Minnesota?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Diabetes trials in Minnesota also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Diabetes clinical trial in Minnesota?
Each study sets its own criteria based on age, Diabetes diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a diabetes clinical trial if I am already on medication?
Usually yes. Most type 2 diabetes trials enroll people on metformin or other oral medicines and test a new treatment on top of them; some require a stable dose for a few months first. Trials that exclude insulin or a specific drug say so in their criteria.
Do I need to know my A1c to apply?
No. Trials state an A1c range, but the study site measures it at the screening visit. You only need to know that you have been diagnosed and which type.
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Diabetes clinical trials study new treatments for Type 1, Type 2, and gestational diabetes, including insulin therapies, diet interventions, and islet-cell transplants.

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