38 Recruiting Trials

Clinical Trials
for Obesity in Minnesota

38 clinical trials for Obesity are currently recruiting participants at study sites in Minnesota. Study-related care is provided at no cost.

38
Recruiting trials
27
Study sites
7
Cities
18
Industry-sponsored
3
Phase 2
15
Phase 3

Obesity clinical trials in Minnesota: what to expect

Obesity trials are among the most actively recruiting studies in the United States right now. Most test medicines from the GLP-1 family (the class that includes semaglutide and tirzepatide) or newer compounds that work on the same appetite and blood-sugar pathways, often in people who also have high blood pressure, sleep apnea, knee osteoarthritis or prediabetes. A smaller number study structured diet and exercise programs, devices, or weight-loss surgery.

In Minnesota, recruiting obesity studies are concentrated in Minneapolis, Rochester, Maplewood and Mankato, with sites in 3 other cities. 18 of the 38 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who obesity trials usually look for

Nearly every study sets a body mass index (BMI) threshold, most often 30 or higher, or 27 or higher when you also have a weight-related condition. Many ask that your weight has been stable for the last three months and that you are not currently using a prescription weight-loss drug. Age limits of 18 to 75 are common. Pregnancy, a history of pancreatitis or certain thyroid cancers, and bariatric surgery within the last few years are the exclusions that come up most.

If you have type 2 diabetes, look for trials that name it: some obesity studies exclude diabetes, while others are designed specifically for people who have both.

What taking part involves

A screening visit with a physical exam, blood work and an ECG usually comes first. Drug trials then run for six months to two years, with study visits every few weeks at the start and every one to three months later on. Most GLP-1 studies use a once-weekly injection you give yourself at home; many are placebo-controlled, meaning some participants receive an inactive version for part or all of the study, and you are told that before you agree to join. Study medication, visits and tests are provided at no cost, and most trials pay a stipend for time and travel.

Questions worth asking the study team

Whether there is a placebo group and how long it lasts; whether you can continue the medicine after the study ends; how many visits are required and how far the site is from you; and what happens if you need to stop early. Sites answer these every day and a ten-minute phone screen is the normal next step.

Showing 20 of 38 recruiting Obesity trials in Minnesota

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
PHASE3 Birmingham, Alabama +4 sites NCT07654374
This trial is looking for adults with obesity or overweight who also have type 2 diabetes. Participants will take either the drug aleniglipron or a placebo for 76 weeks to assess its effects.
Recruiting
Efficacy, Safety, and Pharmacokinetics of Tirzepatide (LY3298176) Once Weekly Versus Placebo in Pediatric Participants 6 to Less Than 12 Years of Age Who Have Obesity (ADVANCE-SURMOUNT-KIDS)
PHASE3 Tucson, Arizona +4 sites NCT07817875
This trial is looking for children aged 6 to less than 12 years who have obesity. Participants will try a new treatment along with healthy lifestyle changes for about two years.
Recruiting
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
PHASE3 Tucson, Arizona +4 sites NCT06672549
This trial is looking for teens aged 12 to under 18 who are struggling with obesity or being overweight. Participants must have tried losing weight before but were unsuccessful.
Recruiting
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
PHASE3 Birmingham, Alabama +4 sites NCT07564414
This trial is looking for people with obesity, with or without type 2 diabetes, who want to lose weight. Participants will be assigned by chance to receive either CagriSema or semaglutide for about 83 weeks.
Recruiting
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes
PHASE3 Birmingham, Alabama +4 sites NCT07743450
This trial is looking for adults with obesity or overweight who have type 2 diabetes. Participants will take a daily oral medication to see how well it works and how safe it is over time.
Recruiting
Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)
PHASE3 Birmingham, Alabama +4 sites NCT07654361
This trial is looking for adults with obesity or overweight who have health problems related to their weight. Participants will take a daily medication called aleniglipron for at least 76 weeks while following a reduced-calorie diet and increasing physical activity.
Recruiting
tDCS With Cognitive Training to Reduce Impulsivity and Weight in Veterans With Obesity
NA Minneapolis, Minnesota NCT05225233
This trial is looking for veterans who are obese and want to reduce impulsivity and weight. Participants will receive cognitive training along with a treatment called tDCS.
Recruiting
Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity
NA Rochester, Minnesota NCT07031297
This trial is looking for premenopausal women who are interested in how fat tissue responds to meals. Participants will undergo a procedure to help researchers study the fat tissue's reaction after eating a meal.
Recruiting
Phenotype-Tailored Lifestyle Intervention for Obesity: A Randomized Trial
NA Rochester, Minnesota NCT06770049
This trial is looking for adults aged 18 to 65 who are struggling with obesity. Participants will work on personalized lifestyle changes to help with weight loss and maintenance.
Recruiting
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
PHASE3 Anniston, Alabama +4 sites NCT07351045
This trial is looking for adults who are overweight or have obesity without type 2 diabetes. Participants will take a study drug or a placebo to help with weight management and will need to self-administer the treatment.
Recruiting
A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)
PHASE3 Saint Paul, Minnesota +4 sites NCT06760546
This trial is looking for patients aged 4 and older with congenital hypothalamic obesity. Participants will take a daily injection of Setmelanotide or a placebo for up to 26 weeks to assess its effects on weight, hunger, and quality of life.
Recruiting
A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity
PHASE4 Minneapolis, Minnesota NCT07728383
This trial is looking for adults with obesity who want to try a new way to take a medication that might help with weight management. Participants will take a special liquid form of the drug semaglutide to see if it can help reduce weight.
Recruiting
First-in-human Study of the Safety, Tolerability, Pharmacokinetics, and Food Effect of ACCG-2671
PHASE1 Dilworth, Minnesota +4 sites NCT07815678
This trial is looking for healthy adults and adults with obesity to test the safety and effects of a new treatment called ACCG-2671. Participants will take the treatment in a few doses and provide information about how their bodies respond.
Recruiting
Project SHINE (Sleep Health INitiative for Equity): Culturally Informing a Sleep Extension Intervention for African American Adults
PHASE1 Minneapolis, Minnesota NCT06226077
This trial is looking for African American adults aged 21 to 75 who have trouble sleeping and are not active. Participants will take part in interviews to share their experiences and may join an intervention aimed at improving sleep and activity levels.
Recruiting
Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation
EARLY_PHASE1 Rochester, Minnesota NCT06416969
This trial is looking for adults aged 18 to 65 who are overweight or obese, especially with extra weight around the abdomen. Participants will follow a specific diet and take part in research to understand how body fat works differently in various people.
Recruiting
Regional Lipolysis Insulin Regulation
EARLY_PHASE1 Rochester, Minnesota NCT06392854
This trial is looking for adults aged 18 to 65 who struggle with obesity, especially those with excess weight around the belly. Participants will consume a specific diet provided by the research unit before the study starts.
Recruiting
Insulin Regulation of Lipolysis and Lipolysis Proteins
EARLY_PHASE1 Rochester, Minnesota NCT03866408
This trial is looking for adults with obesity or healthy weight to understand how a diabetes medication affects fat metabolism. Participants will help researchers learn more about insulin and fat breakdown in the body.
Recruiting
Weight Loss Through Mayo Clinic Diet
NA Rochester, Minnesota NCT06862375
Recruiting
Circadian Rhythms in Human Adipose
NA Rochester, Minnesota NCT06891534
Recruiting
Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis
NA Rochester, Minnesota NCT03868592
This trial is looking for people with obesity who want to understand how weight loss affects insulin and fat breakdown. Participants will be studied before and after having bariatric surgery.
Recruiting

Where the Obesity studies are in Minnesota

  • Mayo Clinic, Rochester7 trials
  • Mayo Clinic in Rochester, Rochester7 trials
  • University of Minnesota, Minneapolis4 trials
  • Children's Minnesota, Saint Paul2 trials
  • Children's Minnesota Pediatric Endocrinology Clinic & McNeeley Diabetes Center, Saint Paul2 trials
  • Fairview Health Services M Health Fairview St Johns Hospital, Maplewood2 trials

Counts are recruiting studies listing at least one site in Minnesota, from ClinicalTrials.gov, refreshed every two days.

Obesity clinical trials in Minnesota: common questions

How many Obesity clinical trials are recruiting in Minnesota?
TrialFinder currently lists 38 recruiting Obesity clinical trials with study sites in Minnesota. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Obesity clinical trials located in Minnesota?
Study sites for the Obesity trials listed on this page include Minneapolis, Rochester, Saint Paul, Dilworth. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Obesity clinical trial in Minnesota?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Obesity trials in Minnesota also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Obesity clinical trial in Minnesota?
Each study sets its own criteria based on age, Obesity diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need a BMI over 30 to join an obesity clinical trial?
Most adult obesity trials require a BMI of 30 or higher, or 27 or higher if you also have a weight-related condition such as high blood pressure, prediabetes or sleep apnea. Each trial page lists its exact threshold.
Are obesity trial participants paid?
Study medication, visits and tests are provided free, and most obesity trials pay a stipend per visit for time and travel. The amount is set by each study and told to you before you enroll; it is never contingent on finishing the study.
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Obesity trials study GLP-1 receptor agonists, bariatric procedures, behavioural interventions, and combination weight-loss therapies in adults and adolescents.

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