Heart Disease Trials / Trials in Minnesota
27 Recruiting Trials

Clinical Trials
for Heart Disease in Minnesota

27 clinical trials for Heart Disease are currently recruiting participants at study sites in Minnesota. Study-related care is provided at no cost.

27
Recruiting trials
15
Study sites
3
Cities
9
Industry-sponsored
2
Phase 2
2
Phase 3

Heart Disease clinical trials in Minnesota: what to expect

Heart disease trials cover heart failure, coronary artery disease, atrial fibrillation, high cholesterol and lipoprotein(a), and the devices and procedures used to treat them. The largest are outcomes trials: thousands of people take a study medicine or placebo on top of their usual treatment for several years while the trial counts heart attacks, strokes and hospital stays. Smaller studies test new heart failure drugs, cholesterol-lowering injections given a few times a year, cardiac rehabilitation programs and monitoring devices.

In Minnesota, recruiting heart disease studies are concentrated in Rochester, Minneapolis and Saint Cloud. 9 of the 27 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who heart disease trials usually look for

Listings define the condition precisely: an ejection fraction range for heart failure, a heart attack or stent within a recent window, cholesterol still above target on a statin, or a lipoprotein(a) level above a threshold. They usually ask that your current heart medicines have been stable for a month or more. Common exclusions are a very recent procedure, advanced kidney disease and another illness that limits life expectancy. Ages generally run from 18 with no upper limit.

What taking part involves

Screening includes an ECG, blood work and often an echocardiogram. Outcomes trials are long but light: a pill or injection added to your treatment, visits every three to six months and phone check-ins between. Drug trials for heart failure run three to twelve months with monthly visits. Device trials involve a procedure and follow-up imaging. Your existing heart medicines continue throughout; study treatment and tests are free, and travel is usually reimbursed.

Questions worth asking the study team

Whether anything about your current treatment would change; how long the trial runs and how often you must come in; what is being measured and what you will be told about your own results; and whether your cardiologist will receive updates.

Showing 20 of 27 recruiting Heart Disease trials in Minnesota

A Study Of Heart Disease Using AI-Enabled Electrocardiography And Focused Cardiac Ultrasound
NA Rochester, Minnesota NCT07351656
This trial is looking for young adults, adults, and pregnant women to help test new heart disease screening methods. Participants will have their heart function assessed using advanced AI technology.
Recruiting
Effect of Sacubitril-Valsartan on Cardiac Structure and Function
PHASE3 Rochester, Minnesota NCT06693674
Recruiting
A Study of Hemodynamic Cardiopulmonary Exercise for CHD
NA Rochester, Minnesota NCT06566196
This trial is looking for people with congenital heart disease who are scheduled for a cardiac catheterization. Participants will help researchers understand how heart function is affected by exercise compared to resting.
Recruiting
Outcomes and Health Care Resource Utilization in Pediatric Congenital Heart Disease Patients Undergoing Non-Cardiac Procedures
N/A Minneapolis, Minnesota +4 sites NCT04604418
This trial is looking for children and young adults with congenital heart disease who are undergoing non-cardiac procedures. Participants will help researchers understand the risks and healthcare needs for these patients.
Recruiting
The Co-Op @ HeartWorks
N/A Rochester, Minnesota NCT06469918
This trial is looking for adults, caregivers of minors, or family members of those who have been diagnosed with congenital heart defects. Participants will help create a database to improve future treatments and studies for congenital heart disease.
Recruiting
Clinical Readiness Skin Punch Biopsy Sample Collections
N/A Rochester, Minnesota NCT06588426
This trial is looking for adults with congenital heart disease to collect skin samples. This will help speed up the process for future treatments they may qualify for.
Recruiting
Pulmonary Hypertension in Left Heart Disease
N/A Rochester, Minnesota NCT05935605
This trial is looking for people with heart disease to compare their condition with varying levels of lung blood flow issues. Participants will undergo heart tests, lung scans, and blood samples.
Recruiting
A Study Of Clinical Implications Of Pulmonary Vascular Disease In Valvular Heart Disease
N/A Rochester, Minnesota NCT07483203
This trial is looking for people with left-sided heart valve problems who are scheduled for surgery on their aortic or mitral valve. Participants will help researchers understand how lung blood flow affects their heart conditions.
Recruiting
Autologous Induced Pluripotent Stem Cells of Cardiac Lineage for Congenital Heart Disease
PHASE1 Rochester, Minnesota NCT05647213
This trial is looking for people with severe heart problems due to congenital heart disease. Participants will receive lab-grown heart cells and will be monitored before and after the treatment.
Recruiting
A Study of Invasive Hemodynamic for MACHD Registry
N/A Rochester, Minnesota NCT05849025
This trial is looking for people with congenital heart disease to gather information for a registry. Participants will undergo tests including an MRI to help in this research.
Recruiting
Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot and Other Congenital Heart Diseases
N/A Rochester, Minnesota NCT05122962
This trial is looking for people with congenital heart diseases to learn about symptoms like shortness of breath and palpitations. Participants will help researchers understand heart structure changes related to these conditions.
Recruiting
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
N/A Birmingham, Alabama +4 sites NCT02852031
This trial is looking for newborns diagnosed with Hypoplastic Left Heart Syndrome (HLHS) who are meant to have a specific heart surgery called the Norwood procedure. The goal is to gather information to help improve care for these infants.
Recruiting
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
PHASE3 La Jolla, California +4 sites NCT06563895
This trial is looking for adults who carry a specific genetic variant that can lead to a heart condition but have not yet shown any symptoms. Participants will receive an experimental drug called acoramidis to see if it can prevent heart issues.
Recruiting
Transition to KPL-387 Monotherapy Dosing & Administration Study
PHASE2 Phoenix, Arizona +4 sites NCT07288216
This trial is looking for adults who have a recent history of well-controlled recurring chest pain caused by inflammation around the heart. They should have been treated with certain medications for at least three months and currently be stable on those treatments. However, people with certain infections, recent serious illnesses, or specific other health issues are not eligible to join.
Recruiting
A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)
NA Minneapolis, Minnesota +4 sites NCT07286578
This trial is looking for adults with significant calcium build-up in their coronary arteries. Participants will undergo imaging tests to see if a specific method helps improve treatment outcomes.
Recruiting
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NA Birmingham, Alabama +4 sites NCT06310031
This trial is looking for adults with advanced heart failure to test a device called the BrioVAD System. Participants will receive the BrioVAD and be monitored for safety and effectiveness compared to another treatment.
Recruiting
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NA Phoenix, Arizona +4 sites NCT06526195
This trial is looking for patients with advanced heart failure who are not dependent on intravenous medications. Participants will be evaluated to see if a device called HeartMate 3 can help their heart function better compared to standard medical treatments.
Recruiting
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
NA Gilbert, Arizona +4 sites NCT03142152
This trial is looking for individuals with heart failure and a specific type of mitral valve problem. Participants will be randomly assigned to receive either the treatment or a control and will need to attend follow-up visits.
Recruiting
Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II
NA Rochester, Minnesota +3 sites NCT06271577
This trial is looking for people who have chest pain and are over 18 years old. Participants will help test a new device that records heart activity using a smartphone to see how well it identifies heart attacks.
Recruiting
Mayo AVC Registry and Biobank
N/A Rochester, Minnesota +1 sites NCT03049254
This trial is looking for people with heart conditions related to arrhythmogenic ventricular cardiomyopathy (AVC) or sudden cardiac events. Participants will provide medical information and samples to help researchers understand the genetic aspects of AVC.
Recruiting
See all 27 Heart Disease trials in Minnesota

Where the Heart Disease studies are in Minnesota

Research sites running the most studies
  • Mayo Clinic, Rochester10 trials
  • Mayo Clinic in Rochester, Rochester5 trials
  • Minneapolis Heart Institute, Minneapolis2 trials
  • Minneapolis Heart Institute Foundation, Minneapolis2 trials
  • Abbott Northwestern Hospital, Minneapolis1 trial
  • Allina Health Minneapolis Heart Institute Foundation, Minneapolis1 trial
By city

Counts are recruiting studies listing at least one site in Minnesota, from ClinicalTrials.gov, refreshed every two days.

Heart Disease clinical trials in Minnesota: common questions

How many Heart Disease clinical trials are recruiting in Minnesota?
TrialFinder currently lists 27 recruiting Heart Disease clinical trials with study sites in Minnesota. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Heart Disease clinical trials located in Minnesota?
Study sites for the Heart Disease trials listed on this page include Rochester, Minneapolis. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Heart Disease clinical trial in Minnesota?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Heart Disease trials in Minnesota also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Heart Disease clinical trial in Minnesota?
Each study sets its own criteria based on age, Heart Disease diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I have to stop my heart medicines to join a trial?
Almost never. Heart disease trials add a study treatment to the medicines you already take, and your own cardiologist continues to manage them. A trial that requires a change says so in its listing.
What is a cardiovascular outcomes trial?
A large, multi-year study in which participants take a study medicine or placebo on top of standard care while the trial counts events such as heart attacks and hospital stays. Visits are infrequent, and the drug is provided free throughout.
Can I join a trial after a heart attack or stent?
Yes. Many trials enroll in the weeks after a heart attack or procedure, because that is when the next event is most likely. The window is stated in the listing, so ask soon after discharge.
Heart Disease Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Heart Disease Trials

Cardiovascular trials study statins, PCSK9 inhibitors, heart failure devices, cardiac rehabilitation protocols, and interventional procedures for coronary artery disease.

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