Heart Disease Trials / Trials in Pennsylvania
25 Recruiting Trials

Clinical Trials
for Heart Disease in Pennsylvania

25 clinical trials for Heart Disease are currently recruiting participants at study sites in Pennsylvania. Study-related care is provided at no cost.

25
Recruiting trials
32
Study sites
10
Cities
11
Industry-sponsored
2
Phase 3

Heart Disease clinical trials in Pennsylvania: what to expect

Heart disease trials cover heart failure, coronary artery disease, atrial fibrillation, high cholesterol and lipoprotein(a), and the devices and procedures used to treat them. The largest are outcomes trials: thousands of people take a study medicine or placebo on top of their usual treatment for several years while the trial counts heart attacks, strokes and hospital stays. Smaller studies test new heart failure drugs, cholesterol-lowering injections given a few times a year, cardiac rehabilitation programs and monitoring devices.

In Pennsylvania, recruiting heart disease studies are concentrated in Philadelphia, Pittsburgh, Wynnewood and Harrisburg, with sites in 6 other cities. 11 of the 25 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who heart disease trials usually look for

Listings define the condition precisely: an ejection fraction range for heart failure, a heart attack or stent within a recent window, cholesterol still above target on a statin, or a lipoprotein(a) level above a threshold. They usually ask that your current heart medicines have been stable for a month or more. Common exclusions are a very recent procedure, advanced kidney disease and another illness that limits life expectancy. Ages generally run from 18 with no upper limit.

What taking part involves

Screening includes an ECG, blood work and often an echocardiogram. Outcomes trials are long but light: a pill or injection added to your treatment, visits every three to six months and phone check-ins between. Drug trials for heart failure run three to twelve months with monthly visits. Device trials involve a procedure and follow-up imaging. Your existing heart medicines continue throughout; study treatment and tests are free, and travel is usually reimbursed.

Questions worth asking the study team

Whether anything about your current treatment would change; how long the trial runs and how often you must come in; what is being measured and what you will be told about your own results; and whether your cardiologist will receive updates.

Showing 20 of 25 recruiting Heart Disease trials in Pennsylvania

BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease
NA Phoenix, Arizona +4 sites NCT07582848
This trial is looking for mothers and their infants who have been diagnosed with congenital heart disease. Participants will receive support to help increase direct breastfeeding.
Recruiting
Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)
NA Phoenix, Arizona +4 sites NCT07582861
This trial is looking for pregnant individuals or mothers of infants diagnosed with congenital heart disease (CHD). Participants will receive usual care plus a virtual psychological intervention to help manage their situation.
Recruiting
Cord Clamping Among Neonates With Congenital Heart Disease
NA Birmingham, Alabama +4 sites NCT06153459
This trial is looking for pregnant individuals whose babies have been diagnosed with congenital heart disease. Participants will be randomly assigned to have their baby's umbilical cord clamped either 30 seconds or 120 seconds after birth and will complete assessments at various ages to monitor outcomes.
Recruiting
Outcomes and Health Care Resource Utilization in Pediatric Congenital Heart Disease Patients Undergoing Non-Cardiac Procedures
N/A Los Angeles, California +4 sites NCT04604418
This trial is looking for children and young adults with congenital heart disease who are undergoing non-cardiac procedures. Participants will help researchers understand the risks and healthcare needs for these patients.
Recruiting
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NA Los Angeles, California +4 sites NCT04124120
This trial is looking for women aged 18 and older who need heart surgery. Participants will help researchers compare two types of artery grafts used in heart operations to see which works better.
Recruiting
Angiography and Electrogram Guided Bachmann Bundle Pacing
NA Wilkes-Barre, Pennsylvania NCT07110922
This trial is looking for people who need a permanent pacemaker or defibrillator. Participants will help compare two methods for placing a wire in a specific part of the heart.
Recruiting
Abbott Structural Heart Device Registry
N/A Los Angeles, California +4 sites NCT06590467
This trial is looking for patients who need or have had heart device implants. Participants will help gather information about the safety and performance of specific heart devices used in hospitals.
Recruiting
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
PHASE3 Phoenix, Arizona +4 sites NCT05918211
This trial is looking for adolescents aged 12 to under 19 who have had the Fontan procedure. Participants will take either udenafil or a placebo to help assess its safety and effectiveness.
Recruiting
Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study
NA Los Angeles, California +4 sites NCT07114718
This trial is looking for infants under 6 months who have a congenital heart defect that needs a special stent to help blood flow. Parents or legal representatives will need to give consent for their child to participate.
Recruiting
A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study
NA Stanford, California +4 sites NCT07525843
This trial is looking for teens aged 12-17 with congenital heart disease. Participants will take part in a 5-week online program that aims to help them improve their ability to handle stress and live better lives.
Recruiting
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
NA Tucson, Arizona +4 sites NCT07214376
This trial is looking for patients with heart failure and pulmonary hypertension. Participants will receive a specific treatment and be monitored for three years to evaluate safety and effectiveness.
Recruiting
Penn Medicine Healthy Heart
NA Philadelphia, Pennsylvania NCT06062394
This trial is looking for patients with high blood pressure and cholesterol issues to help change their health behaviors. Participants will be enrolled in a program that lasts for 6 months.
Recruiting
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
N/A Birmingham, Alabama +4 sites NCT02852031
This trial is looking for newborns diagnosed with Hypoplastic Left Heart Syndrome (HLHS) who are meant to have a specific heart surgery called the Norwood procedure. The goal is to gather information to help improve care for these infants.
Recruiting
Dilated Cardiomyopathy Detection Using AI and Screening With Mobile Technology (DCM-DETECT)
NA Lancaster, Pennsylvania NCT06688396
This trial is looking for adults who have been diagnosed with dilated cardiomyopathy and their first-degree relatives. Participants will use a mobile device to help screen for heart issues.
Recruiting
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
PHASE3 La Jolla, California +4 sites NCT06563895
This trial is looking for adults who carry a specific genetic variant that can lead to a heart condition but have not yet shown any symptoms. Participants will receive an experimental drug called acoramidis to see if it can prevent heart issues.
Recruiting
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NA Birmingham, Alabama +4 sites NCT06310031
This trial is looking for adults with advanced heart failure to test a device called the BrioVAD System. Participants will receive the BrioVAD and be monitored for safety and effectiveness compared to another treatment.
Recruiting
Randomization of Single vs Multiple Arterial Grafts
NA Boulder, Colorado +4 sites NCT03217006
This trial is looking for patients who are having heart surgery to improve blood flow, specifically those under 70 years old with certain heart artery problems. It won't include anyone who's had previous heart surgery, has serious health issues like kidney or liver failure, or is currently having a heart attack. They're also not looking for patients who need emergency surgery or those with very low heart function.
Recruiting
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NA Phoenix, Arizona +4 sites NCT06526195
This trial is looking for patients with advanced heart failure who are not dependent on intravenous medications. Participants will be evaluated to see if a device called HeartMate 3 can help their heart function better compared to standard medical treatments.
Recruiting
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
NA Gilbert, Arizona +4 sites NCT03142152
This trial is looking for individuals with heart failure and a specific type of mitral valve problem. Participants will be randomly assigned to receive either the treatment or a control and will need to attend follow-up visits.
Recruiting
CTSN Embolic Protection Trial
NA North Little Rock, Arkansas +4 sites NCT06027788
This trial is looking for patients aged 60 and older who are scheduled for certain types of heart valve surgeries. By participating, I would be helping to test a device designed to protect the heart during the procedure.
Recruiting
See all 25 Heart Disease trials in Pennsylvania

Where the Heart Disease studies are in Pennsylvania

Research sites running the most studies
  • Children's Hospital of Philadelphia, Philadelphia7 trials
  • University of Pennsylvania, Philadelphia4 trials
  • Allegheny General Hospital, Pittsburgh2 trials
  • Children's Hospital of Pittsburgh, Pittsburgh2 trials
  • University of Pittsburgh Medical Center, Pittsburgh2 trials
  • Abington Memorial Hospital, Abington1 trial
By city

Counts are recruiting studies listing at least one site in Pennsylvania, from ClinicalTrials.gov, refreshed every two days.

Heart Disease clinical trials in Pennsylvania: common questions

How many Heart Disease clinical trials are recruiting in Pennsylvania?
TrialFinder currently lists 25 recruiting Heart Disease clinical trials with study sites in Pennsylvania. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Heart Disease clinical trials located in Pennsylvania?
Study sites for the Heart Disease trials listed on this page include Wilkes-Barre, Philadelphia, Lancaster. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Heart Disease clinical trial in Pennsylvania?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Heart Disease trials in Pennsylvania also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Heart Disease clinical trial in Pennsylvania?
Each study sets its own criteria based on age, Heart Disease diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I have to stop my heart medicines to join a trial?
Almost never. Heart disease trials add a study treatment to the medicines you already take, and your own cardiologist continues to manage them. A trial that requires a change says so in its listing.
What is a cardiovascular outcomes trial?
A large, multi-year study in which participants take a study medicine or placebo on top of standard care while the trial counts events such as heart attacks and hospital stays. Visits are infrequent, and the drug is provided free throughout.
Can I join a trial after a heart attack or stent?
Yes. Many trials enroll in the weeks after a heart attack or procedure, because that is when the next event is most likely. The window is stated in the listing, so ask soon after discharge.
Heart Disease Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Heart Disease Trials

Cardiovascular trials study statins, PCSK9 inhibitors, heart failure devices, cardiac rehabilitation protocols, and interventional procedures for coronary artery disease.

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